Background One of the causes of combined pituitary hormone deficiency (CPHD) is
represented by Prophet of Pit-1 (PROP-1) gene inactivating mutations. This disorder is …

Abstract Background Congenital Hypopituitarism is caused by genetic and environmental
factors. Over 30 genes have been implicated in isolated and/or combined pituitary hormone …

Background: The mutation frequencies of pituitary transcription factors genes in patients with
combined pituitary hormone deficiencies (CPHD) vary substantially between populations …

Background: Non-syndromic combined pituitary hormone deficiency (CPHD) occurs due to
defects in transcription factors that govern early pituitary development and the specification …

Gonadotropin-releasing hormone (GnRH) and olfactory neurons migrate together in
embryologic development, and disruption of this process causes idiopathic …

The prophet of Pit1 (PROP1) gene is essential for normal gonadotropin production in both
humans and mice. Transgenic mice that overexpress PROP1 in gonadotropes and …

Background/Aims: Many genes encoding pituitary transcription factors involved in the
formation of the pituitary gland are identified. Different mutations in these genes have been …

Objective Mutations of the PROP1 gene lead to combined pituitary hormone deficiency
(CPHD), which is characterized by a deficiency of GH, TSH, LH/FSH, PRL and, less …

A state-of-the-art and concise resource presenting the clinical management of pediatric
endocrine diseases and disorders, this third edition of the highly regarded textbook covers …

Genetic defects affecting the hypothalamic-pituitary-target organ axes can cause a variety of
diseases involving restricted or broad disruptions of human development and physiology. At …