Adaptive Resistance to the “Last Hope” Antibiotics Polymyxin B and Colistin in Pseudomonas aeruginosa Is Mediated by the Novel Two-Component Regulatory …

L Fernández, WJ Gooderham, M Bains… - Antimicrobial agents …, 2010 - Am Soc Microbiol
As multidrug resistance increases alarmingly, polymyxin B and colistin are increasingly
being used in the clinic to treat serious Pseudomonas aeruginosa infections. In this …

Two component regulatory systems and antibiotic resistance in Gram-negative pathogens

AY Bhagirath, Y Li, R Patidar, K Yerex, X Ma… - International journal of …, 2019 - mdpi.com
Gram-negative pathogens such as Klebsiella pneumoniae, Acinetobacter baumannii, and
Pseudomonas aeruginosa are the leading cause of nosocomial infections throughout the …

Lipopolysaccharide biosynthesis in Pseudomonas aeruginosa

JD King, D Kocíncová, EL Westman… - Innate …, 2009 - journals.sagepub.com
Pseudomonas aeruginosa causes serious nosocomial infections, and an important
virulence factor produced by this organism is lipopolysaccharide (LPS). This review …

[图书][B] Pathogenesis of bacterial infections in animals

JF Prescott, JI MacInnes, F Van Immerseel, JD Boyce… - 2022 - Wiley Online Library
The fifth edition of Pathogenesis of Bacterial Infections in Animals tries to capture the many
fascinating and rapid developments in our understanding of how major bacterial pathogens …

Agents of last resort: polymyxin resistance

KS Kaye, JM Pogue, TB Tran, RL Nation… - Infectious Disease …, 2016 - id.theclinics.com
The polymyxins, colistin (also known as polymyxin E) and polymyxin B, have a unique and
interesting history. Originally introduced in the 1950s for the treatment of infections due to …

Genetic and Functional Diversity of Pseudomonas aeruginosa Lipopolysaccharide

JS Lam, VL Taylor, ST Islam, Y Hao… - Frontiers in …, 2011 - frontiersin.org
Lipopolysccharide (LPS) is an integral component of the Pseudomonas aeruginosa cell
envelope, occupying the outer leaflet of the outer membrane in this Gram-negative …

Swarming of Pseudomonas aeruginosa Is a Complex Adaptation Leading to Increased Production of Virulence Factors and Antibiotic Resistance

J Overhage, M Bains, MD Brazas, REW Hancock - 2008 - Am Soc Microbiol
In addition to exhibiting swimming and twitching motility, Pseudomonas aeruginosa is able
to swarm on semisolid (viscous) surfaces. Recent studies have indicated that swarming is a …

Regulation of virulence and antibiotic resistance by two-component regulatory systems in Pseudomonas aeruginosa

WJ Gooderham, REW Hancock - FEMS microbiology reviews, 2009 - academic.oup.com
The Gram-negative opportunistic pathogen Pseudomonas aeruginosa ubiquitously inhabits
soil and water habitats and also causes serious, often antibiotic resistant, infections in …

Clinical pharmacokinetics and pharmacodynamics of colistin

N Grégoire, V Aranzana-Climent, S Magréault… - Clinical …, 2017 - Springer
In this review, we provide an updated summary on colistin pharmacokinetics and
pharmacodynamics. Colistin is an old molecule that is frequently used as last-line treatment …

The Pseudomonas aeruginosa Transcriptome in Planktonic Cultures and Static Biofilms Using RNA Sequencing

A Dötsch, D Eckweiler, M Schniederjans… - PloS one, 2012 - journals.plos.org
In this study, we evaluated how gene expression differs in mature Pseudomonas aeruginosa
biofilms as opposed to planktonic cells by the use of RNA sequencing technology that gives …