Adaptive Resistance to the “Last Hope” Antibiotics Polymyxin B and Colistin in Pseudomonas aeruginosa Is Mediated by the Novel Two-Component Regulatory …
L Fernández, WJ Gooderham, M Bains… - Antimicrobial agents …, 2010 - Am Soc Microbiol
As multidrug resistance increases alarmingly, polymyxin B and colistin are increasingly
being used in the clinic to treat serious Pseudomonas aeruginosa infections. In this …
being used in the clinic to treat serious Pseudomonas aeruginosa infections. In this …
Two component regulatory systems and antibiotic resistance in Gram-negative pathogens
AY Bhagirath, Y Li, R Patidar, K Yerex, X Ma… - International journal of …, 2019 - mdpi.com
Gram-negative pathogens such as Klebsiella pneumoniae, Acinetobacter baumannii, and
Pseudomonas aeruginosa are the leading cause of nosocomial infections throughout the …
Pseudomonas aeruginosa are the leading cause of nosocomial infections throughout the …
Lipopolysaccharide biosynthesis in Pseudomonas aeruginosa
JD King, D Kocíncová, EL Westman… - Innate …, 2009 - journals.sagepub.com
Pseudomonas aeruginosa causes serious nosocomial infections, and an important
virulence factor produced by this organism is lipopolysaccharide (LPS). This review …
virulence factor produced by this organism is lipopolysaccharide (LPS). This review …
[图书][B] Pathogenesis of bacterial infections in animals
JF Prescott, JI MacInnes, F Van Immerseel, JD Boyce… - 2022 - Wiley Online Library
The fifth edition of Pathogenesis of Bacterial Infections in Animals tries to capture the many
fascinating and rapid developments in our understanding of how major bacterial pathogens …
fascinating and rapid developments in our understanding of how major bacterial pathogens …
Agents of last resort: polymyxin resistance
The polymyxins, colistin (also known as polymyxin E) and polymyxin B, have a unique and
interesting history. Originally introduced in the 1950s for the treatment of infections due to …
interesting history. Originally introduced in the 1950s for the treatment of infections due to …
Genetic and Functional Diversity of Pseudomonas aeruginosa Lipopolysaccharide
Lipopolysccharide (LPS) is an integral component of the Pseudomonas aeruginosa cell
envelope, occupying the outer leaflet of the outer membrane in this Gram-negative …
envelope, occupying the outer leaflet of the outer membrane in this Gram-negative …
Swarming of Pseudomonas aeruginosa Is a Complex Adaptation Leading to Increased Production of Virulence Factors and Antibiotic Resistance
In addition to exhibiting swimming and twitching motility, Pseudomonas aeruginosa is able
to swarm on semisolid (viscous) surfaces. Recent studies have indicated that swarming is a …
to swarm on semisolid (viscous) surfaces. Recent studies have indicated that swarming is a …
Regulation of virulence and antibiotic resistance by two-component regulatory systems in Pseudomonas aeruginosa
WJ Gooderham, REW Hancock - FEMS microbiology reviews, 2009 - academic.oup.com
The Gram-negative opportunistic pathogen Pseudomonas aeruginosa ubiquitously inhabits
soil and water habitats and also causes serious, often antibiotic resistant, infections in …
soil and water habitats and also causes serious, often antibiotic resistant, infections in …
Clinical pharmacokinetics and pharmacodynamics of colistin
N Grégoire, V Aranzana-Climent, S Magréault… - Clinical …, 2017 - Springer
In this review, we provide an updated summary on colistin pharmacokinetics and
pharmacodynamics. Colistin is an old molecule that is frequently used as last-line treatment …
pharmacodynamics. Colistin is an old molecule that is frequently used as last-line treatment …
The Pseudomonas aeruginosa Transcriptome in Planktonic Cultures and Static Biofilms Using RNA Sequencing
A Dötsch, D Eckweiler, M Schniederjans… - PloS one, 2012 - journals.plos.org
In this study, we evaluated how gene expression differs in mature Pseudomonas aeruginosa
biofilms as opposed to planktonic cells by the use of RNA sequencing technology that gives …
biofilms as opposed to planktonic cells by the use of RNA sequencing technology that gives …