Extracellular DNA acts as a cation chelator and induces the expression of antibiotic
resistance genes regulated by Mg2+ levels. Here we report the characterization of novel …

Extracellular DNA (eDNA) is in the environment, bodily fluids, in the matrix of biofilms, and
accumulates at infection sites. eDNA can function as a nutrient source, a universal biofilm …

Multidrug resistance in Pseudomonas aeruginosa is increasingly becoming a threat for
human health. Indeed, some strains are resistant to almost all currently available antibiotics …

Antimicrobial peptides (AMPs) are small (< 10 kDa) soluble host defense peptides that play
an important role in the mammalian innate immune response, helping to prevent infection by …

Cationic antimicrobial peptides pass across the outer membrane by interacting with
negatively charged lipopolysaccharide (LPS), leading to outer membrane permeabilization …

Medical device-associated infections are becoming a leading cause of morbidity and
mortality worldwide, prompting researchers to find new, more effective ways to control the …

ABSTRACT A defining characteristic of biofilms is antibiotic tolerance that can be up to 1,000-
fold greater than that of planktonic cells. In Pseudomonas aeruginosa, biofilm tolerance to …

The emergence of Pseudomonas aeruginosa as a potential threat in persistent infections
can be attributed to the plethora of virulence factors expressed by it. This review discusses …

Polymyxins are often the only option to treat acquired multidrug-resistant Pseudomonas
aeruginosa. Polymyxin susceptibility in P. aeruginosa PAO1 is associated with the …

The increasing prevalence of persistent biofilm infections, such as wound infections, chronic
lung infections or medical device-related infections, which usually tolerate conventional …