New and emerging approaches to treat psychiatric disorders

KW Scangos, MW State, AH Miller, JT Baker… - Nature medicine, 2023 - nature.com
Psychiatric disorders are highly prevalent, often devastating diseases that negatively impact
the lives of millions of people worldwide. Although their etiological and diagnostic …

[HTML][HTML] Inflammation-related functional and structural dysconnectivity as a pathway to psychopathology

DR Goldsmith, M Bekhbat, ND Mehta, JC Felger - Biological psychiatry, 2023 - Elsevier
Findings from numerous laboratories and across neuroimaging modalities have consistently
shown that exogenous administration of cytokines or inflammatory stimuli that induce …

[HTML][HTML] Psilocybin induces acute and persisting alterations in immune status in healthy volunteers: An experimental, placebo-controlled study

NL Mason, A Szabo, KPC Kuypers, PA Mallaroni… - Brain, Behavior, and …, 2023 - Elsevier
Patients characterized by stress-related disorders such as depression display elevated
circulating concentrations of pro-inflammatory cytokines and a hyperactive HPA axis …

Dendritic Nanomedicine with Boronate Bonds for Augmented Chemo‐Immunotherapy via Synergistic Modulation of Tumor Immune Microenvironment

Y Li, Y Wu, Z Fang, Y Zhang, H Ding, L Ren… - Advanced …, 2024 - Wiley Online Library
Unsatisfied tumor accumulation of chemotherapeutic drugs and a complicated
immunosuppressive microenvironment diminish the immune response rate and the …

Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system

L Zhou, JY Xiong, YQ Chai, L Huang, ZY Tang… - Frontiers in …, 2022 - frontiersin.org
Omega-3 polyunsaturated fatty acids (PUFAs) can play important roles in maintaining
mental health and resistance to stress, and omega-3 PUFAs supplementation can display …

Stress-induced depression and Alzheimer's disease: focus on astrocytes

OV Dolotov, LS Inozemtseva, NF Myasoedov… - International journal of …, 2022 - mdpi.com
Neurodegenerative diseases and depression are multifactorial disorders with a complex
and poorly understood physiopathology. Astrocytes play a key role in the functioning of …

Recent advances in organ‐on‐chips integrated with bioprinting technologies for drug screening

N Tabatabaei Rezaei, H Kumar, H Liu… - Advanced …, 2023 - Wiley Online Library
Currently, the demand for more reliable drug screening devices has made scientists and
researchers develop novel potential approaches to offer an alternative to animal studies …

A Gpr35-tuned gut microbe-brain metabolic axis regulates depressive-like behavior

L Cheng, H Wu, X Cai, Y Zhang, S Yu, Y Hou, Z Yin… - Cell Host & Microbe, 2024 - cell.com
Gene-environment interactions shape behavior and susceptibility to depression. However,
little is known about the signaling pathways integrating genetic and environmental inputs to …

Natural history of long-COVID in a nationwide, population cohort study

CE Hastie, DJ Lowe, A McAuley, NL Mills… - Nature …, 2023 - nature.com
Previous studies on the natural history of long-COVID have been few and selective. Without
comparison groups, disease progression cannot be differentiated from symptoms originating …

Social stress induces autoimmune responses against the brain

Y Shimo, F Cathomas, H Lin, KL Chan… - Proceedings of the …, 2023 - National Acad Sciences
Clinical studies have revealed a high comorbidity between autoimmune diseases and
psychiatric disorders, including major depressive disorder (MDD). However, the …