Our current understanding of the relationship between the dopaminergic system and human
brain disorders is based on two fundamental discoveries: dopamine-replacement herapy …

Antipsychotic treatment resistance in schizophrenia remains a major issue in psychiatry.
Nearly 30% of patients with schizophrenia do not respond to antipsychotic treatment, yet the …

We performed a meta-analysis of over 30 case-control studies of association between
schizophrenia and a bi-allelic, BalI polymorphism in exon 1 of the dopamine D3 receptor …

Haloperidol, one of the representative typical antipsychotics, is on the market for
schizophrenia but shows severe adverse effects such as extrapyramidal symptoms (EPS) or …

Dopamine receptors are G protein-coupled receptors that are critically involved in
locomotion, reward, and cognitive processes. The D2 class of dopamine receptors (DRD2 …

Several studies showed the density of D2 receptors was elevated in postmortem brains from
schizophrenics. Genes which operate at the level of gene activation may be associated with …

The regulation of the dopamine (DA) receptors is of considerable interest, in part because
treatment with antipsychotic drugs is known to upregulate striatal D2-like receptors. While …

In the present study, quantitative in situ hybridization was used to analyse the effect of
haloperidol treatment on D 2 dopamine receptor gene expression in the rat caudate …

Objective: To comparatively assess the incidence of tardive dyskinesia in patients with
schizophrenia receiving either aripiprazole or haloperidol. Method: Data from 2 controlled …

A novel oligonucleotide probe was designed, characterized and utilized to study the
distribution and modulation of the mRNA encoding the D 2 dopamine receptor in the brain of …