Exosomes─ nature's lipid nanoparticles, a rising star in drug delivery and diagnostics

R Tenchov, JM Sasso, X Wang, WS Liaw, CA Chen… - ACS …, 2022 - ACS Publications
Exosomes are a subgroup of nanosized extracellular vesicles enclosed by a lipid bilayer
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …

[HTML][HTML] Exosome engineering: Current progress in cargo loading and targeted delivery

S Fu, Y Wang, X Xia, JC Zheng - NanoImpact, 2020 - Elsevier
Exosomes, a class of small bilayer vesicles derived from virtually all eukaryotic cells, have
been exploited as a promising natural delivery platform due to their low toxicity, excellent …

[HTML][HTML] Extracellular vesicles: a rising star for therapeutics and drug delivery

S Du, Y Guan, A Xie, Z Yan, S Gao, W Li, L Rao… - Journal of …, 2023 - Springer
Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the
same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural …

Exosomes based strategies for brain drug delivery

FU Rehman, Y Liu, M Zheng, B Shi - Biomaterials, 2023 - Elsevier
Exosome application has emerged as a promising nanotechnology discipline for various
diseases therapeutics and diagnoses. Owing to the natural properties of efficient drug …

M2-type exosomes nanoparticles for rheumatoid arthritis therapy via macrophage re-polarization

H Li, Y Feng, X Zheng, M Jia, Z Mei, Y Wang… - Journal of Controlled …, 2022 - Elsevier
Imbalance between the activities of pro-inflammatory M1 and anti-inflammatory M2
macrophages in rheumatoid arthritis (RA) induces synovial inflammation and autoimmunity …

Potential use of exosomes as diagnostic biomarkers and in targeted drug delivery: progress in clinical and preclinical applications

MN Huda, M Nafiujjaman, IG Deaguero… - ACS biomaterials …, 2021 - ACS Publications
Exosomes are cell-derived vesicles containing heterogeneous active biomolecules such as
proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They …

Recent progresses in exosome-based systems for targeted drug delivery to the brain

S Bashyal, C Thapa, S Lee - Journal of Controlled Release, 2022 - Elsevier
Despite the multiple ongoing and novel initiatives for developing brain-targeted drug
delivery systems, insurmountable obstacles remain. A perfect drug delivery device that can …

Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies

PEM de Castilla, L Tong, C Huang, AM Sofias… - Advanced drug delivery …, 2021 - Elsevier
During the past decades, extracellular vesicles (EVs) have emerged as an attractive drug
delivery system. Here, we assess their pre-clinical applications, in the form of a systematic …

Strategies for structural modification of small molecules to improve blood–brain barrier penetration: a recent perspective

B Xiong, Y Wang, Y Chen, S Xing, Q Liao… - Journal of Medicinal …, 2021 - ACS Publications
In the development of central nervous system (CNS) drugs, the blood–brain barrier (BBB)
restricts many drugs from entering the brain to exert therapeutic effects. Although many …

[HTML][HTML] Exosomes derived from mesenchymal stem cells repair a Parkinson's disease model by inducing autophagy

HX Chen, FC Liang, P Gu, BL Xu, HJ Xu… - Cell death & …, 2020 - nature.com
Parkinson's disease (PD) is a progressively debilitating neurodegenerative condition that
leads to motor and cognitive dysfunction. At present, clinical treatment can only improve …