[HTML][HTML] Ferroptosis at the intersection of lipid metabolism and cellular signaling
D Liang, AM Minikes, X Jiang - Molecular cell, 2022 - cell.com
Ferroptosis, a newly emerged form of regulated necrotic cell death, has been demonstrated
to play an important role in multiple diseases including cancer, neurodegeneration, and …
to play an important role in multiple diseases including cancer, neurodegeneration, and …
Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy
C Tay, A Tanaka, S Sakaguchi - Cancer Cell, 2023 - cell.com
Regulatory T cells (Tregs) are abundant in tumor tissues, raising a question of whether
immunosuppressive tumor-infiltrating Tregs (TI-Tregs) can be selectively depleted or …
immunosuppressive tumor-infiltrating Tregs (TI-Tregs) can be selectively depleted or …
Tumour fatty acid metabolism in the context of therapy resistance and obesity
Fatty acid metabolism is known to support tumorigenesis and disease progression as well
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …
Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance
S Vasseur, F Guillaumond - Oncogenesis, 2022 - nature.com
Lipids are essential constituents for malignant tumors, as they are absolutely required for
tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by …
tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by …
Diet, lipids, and antitumor immunity
H Prendeville, L Lynch - Cellular & Molecular Immunology, 2022 - nature.com
Tumour growth and dissemination is largely dependent on nutrient availability. It has
recently emerged that the tumour microenvironment is rich in a diverse array of lipids that …
recently emerged that the tumour microenvironment is rich in a diverse array of lipids that …
MLL4 mediates differentiation and tumor suppression through ferroptosis
The epigenetic regulator, MLL4 (KMT2D), has been described as an essential gene in both
humans and mice. In addition, it is one of the most commonly mutated genes in all of cancer …
humans and mice. In addition, it is one of the most commonly mutated genes in all of cancer …
The use of iron oxide nanoparticles to reprogram macrophage responses and the immunological tumor microenvironment
V Mulens-Arias, JM Rojas, DF Barber - Frontiers in immunology, 2021 - frontiersin.org
The synthesis and functionalization of iron oxide nanoparticles (IONPs) is versatile, which
has enhanced the interest in studying them as theranostic agents over recent years. As …
has enhanced the interest in studying them as theranostic agents over recent years. As …
Lipid-Laden Macrophages and Inflammation in Atherosclerosis and Cancer: An Integrative View
M Lee-Rueckert, J Lappalainen, PT Kovanen… - Frontiers in …, 2022 - frontiersin.org
Atherosclerotic arterial plaques and malignant solid tumors contain macrophages, which
participate in anaerobic metabolism, acidosis, and inflammatory processes inherent in the …
participate in anaerobic metabolism, acidosis, and inflammatory processes inherent in the …
Dynamic regulation of ferroptosis by lipid metabolism
N Naowarojna, TW Wu, Z Pan, M Li… - Antioxidants & Redox …, 2023 - liebertpub.com
Significance: Ferroptosis is featured by the accumulation of polyunsaturated-lipid
peroxidation on cellular membranes in an iron-dependent manner. Ferroptosis has been …
peroxidation on cellular membranes in an iron-dependent manner. Ferroptosis has been …
Lipid metabolism alterations and ferroptosis in cancer: Paving the way for solving cancer resistance
J Lee, D Shin, JL Roh - European Journal of Pharmacology, 2023 - Elsevier
Cancer often perturbs lipid metabolism, which leads to the alteration of metabolism
intermediates, contributing to their deregulated growth and metastasis. Alteration of lipid …
intermediates, contributing to their deregulated growth and metastasis. Alteration of lipid …