Ferroptosis, a newly emerged form of regulated necrotic cell death, has been demonstrated
to play an important role in multiple diseases including cancer, neurodegeneration, and …

Regulatory T cells (Tregs) are abundant in tumor tissues, raising a question of whether
immunosuppressive tumor-infiltrating Tregs (TI-Tregs) can be selectively depleted or …

Fatty acid metabolism is known to support tumorigenesis and disease progression as well
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …

Lipids are essential constituents for malignant tumors, as they are absolutely required for
tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by …

Tumour growth and dissemination is largely dependent on nutrient availability. It has
recently emerged that the tumour microenvironment is rich in a diverse array of lipids that …

The epigenetic regulator, MLL4 (KMT2D), has been described as an essential gene in both
humans and mice. In addition, it is one of the most commonly mutated genes in all of cancer …

The synthesis and functionalization of iron oxide nanoparticles (IONPs) is versatile, which
has enhanced the interest in studying them as theranostic agents over recent years. As …

Atherosclerotic arterial plaques and malignant solid tumors contain macrophages, which
participate in anaerobic metabolism, acidosis, and inflammatory processes inherent in the …

Significance: Ferroptosis is featured by the accumulation of polyunsaturated-lipid
peroxidation on cellular membranes in an iron-dependent manner. Ferroptosis has been …

Cancer often perturbs lipid metabolism, which leads to the alteration of metabolism
intermediates, contributing to their deregulated growth and metastasis. Alteration of lipid …