The in vitro susceptibility testing interpretive criteria (STIC) for TZP against Enterobacterales
were recently updated by the Food and Drug Administration (FDA), Clinical & Laboratory …

Objectives: Augmented renal clearance (ARC) is a state of enhanced renal function
commonly observed in 30%–65% of critically ill patients despite normal serum creatinine …

Piperacillin-tazobactam (PTZ) is one of the most common antibiotics administered to
hospitalized patients. Its broad activity against gram-negative, gram-positive, and anaerobic …

The Gram-positive anaerobic bacterium Clostridioides difficile (CD) can produce intense
exotoxins, contributing to nosocomial infections, and it is the most common cause of health …

Purpose Inadequate piperacillin (PIP) exposure in intensive care unit (ICU) patients
threatens therapeutic success. Model-informed precision dosing (MIPD) might be promising …

Some bacterial resistance mechanisms degrade antibiotics, potentially protecting
neighbouring susceptible cells from antibiotic exposure. We do not yet understand how such …

Clostridioides difficile is a Gram-positive bacteria that causes nosocomial infections,
significantly impacting public health. In the present study, we aimed to describe the clinical …

Our study aimed to describe the population pharmacokinetics (PK) of piperacillin and
tazobactam in patients on extracorporeal membrane oxygenation (ECMO), with and without …

Breakpoints are the values used by clinical microbiology laboratories to interpret the results
of antimicrobial susceptibility testing (AST) and classify isolates as susceptible or resistant …

Objectives Knowledge on the tissue penetration of piperacillin-tazobactam in children with
sepsis is lacking. In this study, the feasibility and performance of microdialysis experiments …