Shigellosis is a clinical syndrome caused by invasion of the epithelium lining the terminal
ileum, colon, and rectum by Shigella species. Although infections occur globally, and in …

The glycocalyx, a thick layer of carbohydrates, surrounds the cell wall of most bacterial and
parasitic pathogens. Recognition of these unique glycans by the human immune system …

Summary Background Shigella and enterotoxigenic Escherichia coli (ETEC) are bacterial
pathogens that are frequently associated with diarrhoeal disease, and are a significant …

Background Diarrhoea is the second leading cause of mortality in children worldwide, but
establishing the cause can be complicated by diverse diagnostic approaches and varying …

Shigella is the leading cause of global diarrheal deaths that currently lacks a licensed
vaccine. Shigellosis drives antimicrobial resistance and leads to economic impact through …

We need to apply novel findings towards sustainable approaches for treating and preventing
Shigella infections. Vaccines and alternative treatments are under development and may …

Shigella are gram-negative bacteria that cause severe diarrhea and dysentery. In 2013,
Shigella infections caused an estimated 34,400 deaths in children less than five years old …

Background Shigellosis is an acute, severe bacterial colitis that, in high-income countries, is
typically associated with travel to high-risk regions (Africa, Asia, and Latin America). Since …

Shigellosis is a leading cause of diarrheal disease in low-middle-income countries (LMICs).
Effective vaccines will help to reduce the disease burden, exacerbated by increasing …

The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …