Hypertensive nephropathy is the most common complication of hypertension, and is one of
the main causes of end‑stage renal disease (ESRD) in numerous countries. The basic …

Ventricular remodeling is related to the renin-angiotensin-aldosterone system, immune
system, and various cytokines involved in inflammation, apoptosis, and cell signal …

Copper is a trace element necessary for the normal functioning of organisms, but excessive
copper contents may be toxic to the heart. The goal of this study was to investigate the role of …

Osteoarthritis (OA) is a chronic inflammatory joint disease characterized by degradation of
articular cartilage. Ubiquitin-fold modifier 1 (UFM1)-specific ligase 1 (UFL1) is an UFM1 E3 …

Background: Dingji Fumai Decoction (DFD), a traditional herbal mixture, has been widely
used to treat arrhythmia in clinical practice in China. However, the exploration of the active …

Background: Increasing evidence indicates that vitamin D deficiency negatively affects the
cardiovascular system. Here we studied the therapeutic effects of calcitriol in myocardial …

A long-term high-salt intake (HSI) seems to accelerate cardiac aging and age-related
diseases, but the molecular mechanism is still not entirely clear. Exercise is an effective way …

Cardiac hypertrophy and remodeling are among the major health challenges facing
countries around the world today. Neohesperidin plays an important role in influencing cell …

Xin‐Ji‐Er‐Kang (XJEK) inhibited cardiovascular remodeling in hypertensive mice in our
previous studies. We hypothesized that XJEK may prevent isoproterenol (ISO)‐induced …

Abstract Background Xin-Ji-Er-Kang (XJEK) as a herbal formula of traditional Chinese
medicine (TCM) has shown the protective effects on myocardial function as well as renal …