Chronic infections promote the terminal differentiation (or" exhaustion") of T cells and are
thought to preclude the formation of memory T cells. In contrast, we discovered a small …

Memory CD8 T cells that circulate in the blood and are present in lymphoid organs are an
essential component of long-lived T cell immunity. These memory CD8 T cells remain …

Our current understanding of immunology was largely defined in laboratory mice, partly
because they are inbred and genetically homogeneous, can be genetically manipulated …

During chronic viral infection, CD8+ T cells develop into three major phenotypically and
functionally distinct subsets: Ly108+ TCF-1+ progenitors, Ly108− CX3CR1− terminally …

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections
and cancers in animal models and humans. Tex cells are characterized by progressive loss …

Protective immunity against pathogens depends on the efficient generation of functionally
diverse effector and memory T lymphocytes. However, whether plasticity during effector-to …

Infection triggers expansion and effector differentiation of T cells specific for microbial
antigens in association with metabolic reprograming. We found that the glycolytic enzyme …

Several studies have demonstrated that memory T cells including stem cell memory (Tscm)
T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity …

T cells have crucial roles in protection against infection and cancer. Although the trafficking
of memory T cells around the body is integral to their capacity to provide immune protection …

Patients who receive chimeric antigen receptor (CAR)–T cells that are enriched in memory T
cells exhibit better disease control as a result of increased expansion and persistence of the …