Metabolic programming and mitochondrial dynamics along with T cell differentiation affect T
cell fate and memory development; however, how to control metabolic reprogramming and …

Central memory CD8+ T cells (Tcm) control systemic secondary infections and can protect
from chronic infection and cancer as a result of their stem-cell-like capacity to expand …

Generation of tumor-infiltrating lymphocytes begins when tumor antigens reach the lymph
node (LN) to stimulate T cells, yet we know little of how tumor material is disseminated …

Immunological memory is a cardinal feature of adaptive immunity and an important goal of
vaccination strategies. Here we highlight advances in the understanding of the diverse T …

During an infection, T cells can differentiate into multiple types of effector and memory T
cells, which help to mediate pathogen clearance and provide long-term protective immunity …

The tumor microenvironment (TME) is essential for immune escape by tumor cells. It plays
essential roles in tumor development and metastasis. The clinical outcomes of tumors are …

T cell migration is essential for T cell responses; it allows for the detection of cognate antigen
at the surface of antigen-presenting cells and for interactions with other cells involved in the …

THE MAMMALIAN IMMUNE SYSTEM can be broadly divided into two main arms: innate and
adaptive immunity. As its name implies, the cells and receptors of the innate immune system …

Gliomas are brain tumors characterized by an immunosuppressive microenvironment.
Immunostimulatory agonistic CD40 antibodies (αCD40) are in clinical development for solid …

During an immune response to microbial infection, CD8+ T cells give rise to distinct classes
of cellular progeny that coordinately mediate clearance of the pathogen and provide long …