Parkinson disease (PD) is a neurodegenerative disorder marked by the preferential
dysfunction and death of dopaminergic neurons in the substantia nigra. The onset and …

Parkinson's disease (PD) is a global health challenge, yet historically studies of PD have
taken place predominantly in European populations. Recent genetics research conducted in …

Background An understanding of the genetic mechanisms underlying diseases in
ancestrally diverse populations is an important step towards development of targeted …

Genome-wide association studies (GWASs) have identified numerous susceptibility loci for
Parkinson's disease (PD), but its genetic architecture remains underexplored in populations …

The selective vulnerability of specific neuronal subtypes is a hallmark of neurodegenerative
diseases. In this Review, I summarize our current understanding of the brain regions and …

Background Understanding the genetic mechanisms underlying diseases in ancestrally
diverse populations is a critical step towards the realization of the global application of …

Background Recent studies have advanced our understanding of the genetic drivers of
Parkinson's disease (PD). Rare variants in more than 20 genes are considered causal for …

Although many rare variants have been reportedly associated with Parkinson's disease
(PD), many have not been replicated or have failed to replicate. Here, we conduct a large …

There are 90 independent genome-wide significant genetic risk variants for Parkinson's
disease (PD) but currently only five nominated loci for PD progression. The biology of PD …

While machine learning (ML) research has recently grown more in popularity, its application
in the omics domain is constrained by access to sufficiently large, high-quality datasets …