Abstract Background The Wnt signaling pathway is a complex network of protein interactions
that functions most commonly in embryonic development and cancer, but is also involved in …

Epithelial–mesenchymal transition (EMT) is a process during which cells lose their epithelial
characteristics, for instance apical–basal cell polarity and cell–cell contact, and gain …

Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

Glioblastoma multiforme (GBM) is the most common form of brain cancer and one of the
most aggressive cancers found in humans. Most of the signs and symptoms of GBM can be …

Long noncoding RNAs (lncRNAs) comprise a class of RNAs that do not code for proteins but
are critical in regulating diverse cellular processes and maintaining cell function. In doing so …

Background Lymphatic metastasis has been associated with poor prognosis in bladder
cancer patients with limited therapeutic options. Emerging evidence shows that heat shock …

DNA‐binding proteins, including transcription factors (TFs), play essential roles in various
cellular processes and pathogenesis of diseases, deeming to be potential therapeutic …

Background Colorectal cancer liver metastases (CRCLM) are associated with a poor
prognosis, reflected by a five-year survival rate of 14%. Anti-angiogenic therapy through anti …

Targeted protein degradation (TPD), represented by proteolysis-targeting chimera
(PROTAC), has emerged as a novel therapeutic modality in drug discovery. However, the …

The WNT (Wingless/Integrated) signaling pathway is implicated in various stages of
glioblastoma, which is an aggressive brain tumor for which therapeutic options are limited …