A gap exists between guidelines and real-world clinical practice for the management and
treatment of chronic obstructive pulmonary disease (COPD). Although this has narrowed in …

Bronchodilators are the cornerstone of pharmacological management of COPD. For patients
whose conditions are not sufficiently controlled by monotherapy, combining bronchodilators …

Currently available inhaled bronchodilators used as therapy for chronic obstructive
pulmonary disease (COPD) necessitate multiple daily dosing. The present study evaluates …

The degree of acute improvement in spirometric indices after bronchodilator inhalation
varies among chronic obstructive pulmonary disease (COPD) patients, and depends upon …

Context The care of patients with chronic obstructive pulmonary disease (COPD) has
changed radically over the past 2 decades, and novel therapies can not only improve the …

Evidence-based medicine is a corner stone in treatment decision making and large
randomised, clinical trials are usually designed in order to provide highly significant results …

Background Patients with COPD often require multiple therapies to improve lung function
and decrease symptoms and exacerbations. Salmeterol and theophylline are indicated for …

Chronic obstructive pulmonary disease (COPD) represents a significant cause of global
morbidity and mortality, with a substantial economic impact. Recent changes in the Global …

Study objective To compare the bronchodilator efficacyand safety of tiotropium and placebo.
Design A3-month, randomized, double-blind, placebo-controlled, multicentertrial. Setting …

Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow
limitation and debilitating symptoms. For patients with moderate-to-severe COPD, long …