Despite several decades of intense research focused on understanding function (s) and
disease-associated malfunction of p53, there is no sign of any “mid-life crisis” in this rapidly …

Transcription of the ribosomal RNA genes (rDNA) that encode the three largest ribosomal
RNAs (rRNA), is mediated by RNA Polymerase I (Pol I) and is a key regulatory step for …

Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their molecular
mechanism in human disease remains obscure. Here we show that circular antisense non …

The nucleolus is a prominent subnuclear compartment, where ribosome biosynthesis takes
place. Recently, the nucleolus has gained attention for its novel role in the regulation of …

The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …

Simple Summary Cells need to produce ribosomes to sustain continuous proliferation and
expand in numbers, a feature that is even more prominent in uncontrollably proliferating …

FAK is a tyrosine kinase overexpressed in cancer cells and plays an important role in the
progression of tumors to a malignant phenotype. Except for its typical role as a cytoplasmic …

Ribosomopathies are a diverse subset of diseases caused by reduced expression of, or
mutations in, factors necessary for making ribosomes, the protein translation machinery in …

Ribosome biogenesis is a complex and energy-demanding process requiring tight
coordination of ribosomal RNA (rRNA) and ribosomal protein (RP) production. Given the …

The nucleolus is a potent disease biomarker and a target in cancer therapy. Ribosome
biogenesis is initiated in the nucleolus where most ribosomal (r-) proteins assemble onto …