Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses among all
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …

Pancreatic cancer is an aggressive malignancy with increasing incidence and poor
prognosis due to its late diagnosis and intrinsic chemoresistance. Most pancreatic cancer …

Cancer heterogeneity constitutes the major source of disease progression and therapy
failure. Tumors comprise functionally diverse subpopulations, with cancer stem cells (CSCs) …

Wnt/β‐catenin pathway is one of the main/frequent dysregulated pathways in several tumor
types, including colon cancer. Aberrant activation of this pathway is associated with cell …

ABSTRACT PI3K/AKT/mTOR signaling pathway is one of the key dysregulated pathways in
different tumor types, including colorectal cancer (CRC). Activation of this pathway is shown …

Cancer metastasis to distant organs is initiated by tumor cells that disseminate from primary
heterogeneous tumors. The subsequent growth and survival of tumor metastases depend on …

Cervical cancer is a common gynecological cancer and a leading cause of cancer‐related
death in women globally. There is a need for the identification of prognostic and predictive …

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive neoplasm, predicted
to become the second leading cause of cancer-related deaths before 2030. This dismal …

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal form of cancer characterized by
drug resistance, urging new therapeutic strategies. In recent years, protein kinases have …

A new series of eighteen imidazo [2, 1-b][1, 3, 4] thiadiazole derivatives was efficiently
synthesized and screened for antiproliferative activity against the National Cancer Institute …