In this study, we combined AlphaFold-based atomistic structural modeling, microsecond
molecular simulations, mutational profiling, and network analysis to characterize binding …

Genomic surveillance of pathogen evolution is essential for public health response,
treatment strategies, and vaccine development. In the context of SARS-COV-2, multiple …

In this study, we performed a computational study of binding mechanisms for the SARS-CoV-
2 spike Omicron XBB lineages with the host cell receptor ACE2 and a panel of diverse class …

Summary In July/August 2023, the highly mutated severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) BA. 2.86 lineage emerged and its descendant JN. 1 is on track …

The ongoing emergence of SARS-CoV-2 variants of concern (VOCs) that reduce the
effectiveness of antibody therapeutics necessitates development of next-generation …

Lassa virus is estimated to cause thousands of human deaths per year, primarily due to
spillovers from its natural host, Mastomys rodents. Efforts to create vaccines and antibody …

The continuous evolution of SARS-CoV-2, particularly the emergence of the BA. 2.86/JN. 1
lineage replacing XBB lineages, necessitates a re-evaluation of current vaccine strategies …

The recently detected Omicron BA. 2.86 lineage contains more than 30 amino acid
mutations relative to BA. 2. Here, we identify the epitopes driving immune escape of BA. 2.86 …

The seasonal human influenza virus undergoes rapid evolution, leading to significant
changes in circulating viral strains from year to year. These changes are typically driven by …

The continued evolution of SARS-CoV-2 requires persistent monitoring of its subvariants.
Omicron subvariants are responsible for the vast majority of SARS-CoV-2 infections …