Mast cells have existed long before the development of adaptive immunity, although they
have been given different names. Thus, in the marine urochordate Styela plicata, they have …

The origin and functions of mast cells (MCs) have been debated since their description by
Paul Ehrlich in 1879. MCs have long been considered'reactive bystanders' and'amplifiers' in …

Lung inflammation is a hallmark of Coronavirus disease 2019 (COVID-19) in patients who
are severely ill, and the pathophysiology of disease is thought to be immune mediated. Mast …

Since first described by Paul Ehrlich in 1878, mast cells have been mostly viewed as
effectors of allergy. It has been only in the past two decades that mast cells have gained …

Mastocytosis is a heterogeneous group of neoplasms defined by a numerical increase and
accumulation of clonal mast cells (MCs) in various organ systems. The disease may present …

Centralized pain syndromes are associated with changes within the central nervous system
that amplify peripheral input and/or generate the perception of pain in the absence of a …

Mast-cell activation mediated by the high-affinity receptor for IgE (FcεRI) is considered to be
a key event in the allergic inflammatory response. However, in a physiological setting, other …

Mast cells have been recognized for well over 100 years. With time, human mast cells have
been documented to originate from CD34+ cells, and have been implicated in host …

The cornea is a special interface between the internal ocular tissue and the external
environment that provides a powerful chemical, physical, and biological barrier against the …

Mas-related G-protein coupled receptor member X2 (MRGPRX2) is a class A GPCR
expressed on mast cells. Mast cells are granulated tissue-resident cells known for host cell …