The aetiology and molecular landscape of insulin resistance
Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …
[HTML][HTML] Hyperinsulinemia in obesity, inflammation, and cancer
AMY Zhang, EA Wellberg, JL Kopp… - … & metabolism journal, 2021 - synapse.koreamed.org
The relative insufficiency of insulin secretion and/or insulin action causes diabetes.
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …
Insulin resistance and insulin hypersecretion in the metabolic syndrome and type 2 diabetes: Time for a conceptual framework shift
While few dispute the existence of the metabolic syndrome as a clustering of factors
indicative of poor metabolic health, its utility above that of its individual components in the …
indicative of poor metabolic health, its utility above that of its individual components in the …
Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation
The rising pancreatic cancer incidence due to obesity and type 2 diabetes is closely tied to
hyperinsulinemia, an independent cancer risk factor. Previous studies demonstrated …
hyperinsulinemia, an independent cancer risk factor. Previous studies demonstrated …
On the causal relationships between hyperinsulinaemia, insulin resistance, obesity and dysglycaemia in type 2 diabetes
JD Johnson - Diabetologia, 2021 - Springer
Hundreds of millions of people are affected by hyperinsulinaemia, insulin resistance, obesity
and the dysglycaemia that mark a common progression from metabolic health to type 2 …
and the dysglycaemia that mark a common progression from metabolic health to type 2 …
[HTML][HTML] Obesity: Pathophysiology, monosodium glutamate-induced model and anti-obesity medicinal plants
RJH Bautista, AM Mahmoud, M Königsberg… - Biomedicine & …, 2019 - Elsevier
Obesity and overweight have increased at an alarming rate in the world during the last three
decades. Obesity is a crucial factor in the development of metabolic abnormalities, including …
decades. Obesity is a crucial factor in the development of metabolic abnormalities, including …
Growth hormone deficiency: health and longevity
MH Aguiar-Oliveira, A Bartke - Endocrine reviews, 2019 - academic.oup.com
The important role of GH in the control of mammalian longevity was first deduced from
extended longevity of mice with genetic GH deficiency (GHD) or GH resistance. Mice with …
extended longevity of mice with genetic GH deficiency (GHD) or GH resistance. Mice with …
Fructose metabolism and metabolic disease
SA Hannou, DE Haslam, NM McKeown… - The Journal of …, 2018 - Am Soc Clin Investig
Increased sugar consumption is increasingly considered to be a contributor to the worldwide
epidemics of obesity and diabetes and their associated cardiometabolic risks. As a result of …
epidemics of obesity and diabetes and their associated cardiometabolic risks. As a result of …
Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence
Prediabetes and Alzheimer's disease both increase in prevalence with age. The former is a
risk factor for the latter, but a mechanistic linkage between them remains elusive. We show …
risk factor for the latter, but a mechanistic linkage between them remains elusive. We show …
Insulin: too much of a good thing is bad
H Kolb, K Kempf, M Röhling, S Martin - BMC medicine, 2020 - Springer
Background Insulin shares a limited physiological concentration range with other endocrine
hormones. Not only too low, but also too high systemic insulin levels are detrimental for body …
hormones. Not only too low, but also too high systemic insulin levels are detrimental for body …