Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …

The relative insufficiency of insulin secretion and/or insulin action causes diabetes.
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …

While few dispute the existence of the metabolic syndrome as a clustering of factors
indicative of poor metabolic health, its utility above that of its individual components in the …

The rising pancreatic cancer incidence due to obesity and type 2 diabetes is closely tied to
hyperinsulinemia, an independent cancer risk factor. Previous studies demonstrated …

Hundreds of millions of people are affected by hyperinsulinaemia, insulin resistance, obesity
and the dysglycaemia that mark a common progression from metabolic health to type 2 …

Obesity and overweight have increased at an alarming rate in the world during the last three
decades. Obesity is a crucial factor in the development of metabolic abnormalities, including …

The important role of GH in the control of mammalian longevity was first deduced from
extended longevity of mice with genetic GH deficiency (GHD) or GH resistance. Mice with …

Increased sugar consumption is increasingly considered to be a contributor to the worldwide
epidemics of obesity and diabetes and their associated cardiometabolic risks. As a result of …

Prediabetes and Alzheimer's disease both increase in prevalence with age. The former is a
risk factor for the latter, but a mechanistic linkage between them remains elusive. We show …

Background Insulin shares a limited physiological concentration range with other endocrine
hormones. Not only too low, but also too high systemic insulin levels are detrimental for body …