Autism spectrum disorder: neuropathology and animal models

M Varghese, N Keshav, S Jacot-Descombes… - Acta …, 2017 - Springer
Autism spectrum disorder (ASD) has a major impact on the development and social
integration of affected individuals and is the most heritable of psychiatric disorders. An …

The valproic acid-induced rodent model of autism

C Nicolini, M Fahnestock - Experimental neurology, 2018 - Elsevier
Autism is a lifelong neurodevelopmental disorder characterized by impairments in social
communication and interaction and by repetitive patterns of behavior, interests and activities …

A systematic review of the valproic-acid-induced rodent model of autism

D Chaliha, M Albrecht, M Vaccarezza… - Developmental …, 2020 - karger.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by
repetitive behaviours, cognitive rigidity/inflexibility, and social-affective impairment …

Adult microbiota‐deficient mice have distinct dendritic morphological changes: Differential effects in the amygdala and hippocampus

P Luczynski, SO Whelan, C O'Sullivan… - European Journal of …, 2016 - Wiley Online Library
Increasing evidence implicates the microbiota in the regulation of brain and behaviour.
Germ‐free mice (GF; microbiota deficient from birth) exhibit altered stress hormone …

Dendrite and spine modifications in autism and related neurodevelopmental disorders in patients and animal models

V Martínez‐Cerdeño - Developmental neurobiology, 2017 - Wiley Online Library
Dendrites and spines are the main neuronal structures receiving input from other neurons
and glial cells. Dendritic and spine number, size, and morphology are some of the crucial …

[HTML][HTML] Decoding the neurocircuitry of gut feelings: Region-specific microbiome-mediated brain alterations

BL Sharvin, MR Aburto, JF Cryan - Neurobiology of Disease, 2023 - Elsevier
Research in the last decade has unveiled a crucial role for the trillions of microorganisms
that reside in the gut in influencing host neurodevelopment across the lifespan via the …

The basolateral amygdala γ‐aminobutyric acidergic system in health and disease

EM Prager, HC Bergstrom, GH Wynn… - Journal of …, 2016 - Wiley Online Library
The brain comprises an excitatory/inhibitory neuronal network that maintains a finely tuned
balance of activity critical for normal functioning. Excitatory activity in the basolateral …

Maternal polycystic ovary syndrome and the risk of autism spectrum disorders in the offspring: a population-based nationwide study in Sweden

K Kosidou, C Dalman, L Widman, S Arver, BK Lee… - Molecular …, 2016 - nature.com
Although many studies indicate the interplay of genetic and environmental factors in the
etiology of autism spectrum disorder (ASD), our limited understanding of the underlying …

Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism

K Takuma, Y Hara, S Kataoka, T Kawanai… - Pharmacology …, 2014 - Elsevier
We recently showed that prenatal exposure to valproic acid (VPA) in mice causes autism-
like behavioral abnormalities, including social interaction deficits, anxiety-like behavior and …

Genetic and non-genetic animal models for autism spectrum disorders (ASD)

Z Ergaz, L Weinstein-Fudim, A Ornoy - Reproductive Toxicology, 2016 - Elsevier
Autism spectrum disorder (ASD) is associated, in addition to complex genetic factors, with a
variety of prenatal, perinatal and postnatal etiologies. We discuss the known animal models …