Magnesium plays an important role in many physiological functions. Habitually low intakes
of magnesium and in general the deficiency of this micronutrient induce changes in …

Abstract Magnesium (Mg 2+) is an essential ion to the human body, playing an instrumental
role in supporting and sustaining health and life. As the second most abundant intracellular …

Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide. Discovered 30
years ago, it is produced as a consequence of alternative RNA processing of the calcitonin …

In this review, we discuss the importance of capsaicin to the current understanding of
neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We …

Migraine is the most prevalent neurological disorder worldwide and it has immense
socioeconomic impact. Currently, preventative treatment options for migraine include drugs …

Migraine is a neurological disorder that manifests as a debilitating headache associated
with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) …

Migraine is a common disabling primary headache disorder that affects an estimated 36
million A mericans. Migraine headaches often occur over many years or over an individual's …

Aim The aim of this trial was to evaluate the efficacy and tolerability of ubrogepant (MK-
1602), a calcitonin gene-related peptide receptor antagonist (CGRP-RA), for the acute …

Objective: To evaluate whether the calcitonin gene-related peptide (CGRP) receptor
antagonist telcagepant might be effective for migraine prevention. Methods: In this …

Calcitonin gene-related peptide (CGRP) receptor antagonists have demonstrated anti-
migraine efficacy. One remaining question is where do these blockers act? We hypothesized …