Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection
LCK Bell, M Noursadeghi - Nature Reviews Microbiology, 2018 - nature.com
Co-infection with Mycobacterium tuberculosis is the leading cause of death in individuals
infected with HIV-1. It has long been known that HIV-1 infection alters the course of M …
infected with HIV-1. It has long been known that HIV-1 infection alters the course of M …
HIV‐Related Immune Activation and Inflammation: Current Understanding and Strategies
T Lv, W Cao, T Li - Journal of immunology research, 2021 - Wiley Online Library
Although antiretroviral therapy effectively controls human immunodeficiency virus (HIV)
replication, a residual chronic immune activation/inflammation persists throughout the …
replication, a residual chronic immune activation/inflammation persists throughout the …
The pathogenesis of tuberculous meningitis
AG Davis, UK Rohlwink, A Proust… - Journal of leukocyte …, 2019 - academic.oup.com
Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the
brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM) …
brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM) …
Indole propionic acid, an unusual antibiotic produced by the gut microbiota, with anti-inflammatory and antioxidant properties
Most antibiotics are produced by soil microbes and typically interfere with macromolecular
synthesis processes as their antibacterial mechanism of action. These natural products are …
synthesis processes as their antibacterial mechanism of action. These natural products are …
TLRs/NLRs: Shaping the landscape of host immunity
Innate immune system provides the first line of defense against pathogenic organisms. It has
a varied and large collection of molecules known as pattern recognition receptors (PRRs) …
a varied and large collection of molecules known as pattern recognition receptors (PRRs) …
Genetics of human susceptibility to active and latent tuberculosis: present knowledge and future perspectives
Tuberculosis is an ancient human disease, estimated to have originated and evolved over
thousands of years alongside modern human populations. Despite considerable advances …
thousands of years alongside modern human populations. Despite considerable advances …
The Immune Response to Mycobacterium tuberculosis in HIV-1-Coinfected Persons
Globally, about 36.7 million people were living with HIV infection at the end of 2015. The
most frequent infection co-occurring with HIV-1 is Mycobacterium tuberculosis—374,000 …
most frequent infection co-occurring with HIV-1 is Mycobacterium tuberculosis—374,000 …
Host defense mechanisms against Mycobacterium tuberculosis
Q Chai, Z Lu, CH Liu - Cellular and Molecular Life Sciences, 2020 - Springer
Tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), remains the
leading cause of death worldwide from a single infectious pathogen. Mtb is a paradigmatic …
leading cause of death worldwide from a single infectious pathogen. Mtb is a paradigmatic …
Tuberculosis IRIS: pathogenesis, presentation, and management across the spectrum of disease
CM Quinn, V Poplin, J Kasibante, K Yuquimpo… - Life, 2020 - mdpi.com
Antiretroviral therapy (ART), while essential in combatting tuberculosis (TB) and HIV
coinfection, is often complicated by the TB-associated immune reconstitution inflammatory …
coinfection, is often complicated by the TB-associated immune reconstitution inflammatory …
Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected Macrophages
Lysosomal cathepsin B (CTSB) has been proposed to play a role in the induction of acute
inflammation. We hypothesised that the presence of active CTSB in the cytosol is crucial for …
inflammation. We hypothesised that the presence of active CTSB in the cytosol is crucial for …