Defensive and emotional behavior modulation by serotonin in the periaqueductal gray

P Vázquez-León, A Miranda-Páez… - Cellular and Molecular …, 2023 - Springer
Abstract Serotonin 5-hydroxytryptamine (5-HT) is a key neurotransmitter for the modulation
and/or regulation of numerous physiological processes and psychiatric disorders (eg …

The periaqueductal gray and its extended participation in drug addiction phenomena

P Vázquez-León, A Miranda-Páez… - Neuroscience …, 2021 - Springer
The periaqueductal gray (PAG) is a complex mesencephalic structure involved in the
integration and execution of active and passive self-protective behaviors against imminent …

CB1 receptor signalling mediates cannabidiol-induced panicolytic-like effects and defensive antinociception impairment in mice threatened by Bothrops jararaca …

BM de Paula Rodrigues… - Journal of …, 2022 - journals.sagepub.com
Background: Cannabis sativa-derived substances such as cannabidiol (CBD) have attracted
increasing clinical interest and consist in a new perspective for treating some neurological …

The anterior cingulate cortex and its interface with the dorsal periaqueductal grey regulating nitric oxide-mediated panic-like behaviour and defensive antinociception

LL Falconi-Sobrinho, T dos Anjos-Garcia, MA Rebelo… - …, 2024 - Elsevier
The anterior cingulate cortex (ACC) Cg1 (24b) area modulates glutamate-mediated
unconditioned fear and antinociception organised by hypothalamus. However, it remains …

Identification of a novel perifornical-hypothalamic-area-projecting serotonergic system that inhibits innate panic and conditioned fear responses

CS Bernabe, IF Caliman, ARR de Abreu… - Translational …, 2024 - nature.com
Abstract The serotonin (5-HT) system is heavily implicated in the regulation of anxiety and
trauma-related disorders such as panic disorder and post-traumatic stress disorder …

[HTML][HTML] Neuroanatomy, periaqueductal gray

M Mokhtar, P Singh - 2020 - europepmc.org
The periaqueductal gray (PAG) is a key structure in the propagation and modulation of pain,
sympathetic responses as well as the learning and action of defensive and aversive …

The rodent-versus-wild snake paradigm as a model for studying anxiety-and panic-like behaviors: face, construct and predictive validities

T Paschoalin-Maurin, T dos Anjos-Garcia… - Neuroscience, 2018 - Elsevier
Using an innovative approach to study the neural bases of psychiatric disorders, this study
investigated the behavioral, morphological and pharmacological bases of panic attack …

GABAergic and glutamatergic inputs to the medulla oblongata and locus coeruleus noradrenergic pathways are critical for seizures and postictal antinociception …

M Mendonça-dos-Santos, TCT Gonçalves… - Scientific Reports, 2024 - nature.com
We investigated the participation of the nucleus of the tractus solitarius (NTS) in tonic‒clonic
seizures and postictal antinociception control mediated by NMDA receptors, the role of NTS …

Critical neuropsychobiological analysis of panic attack-and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex …

NC Coimbra, T Paschoalin-Maurin, GS Bassi… - Revista Brasileira de …, 2017 - SciELO Brasil
Objective: To compare prey and snake paradigms performed in complex environments to
the elevated plus-maze (EPM) and T-maze (ETM) tests for the study of panic attack-and …

Opioid neurotransmission modulates defensive behavior and fear-induced antinociception in dangerous environments

NC Coimbra, F Calvo, RC Almada, RL Freitas… - Neuroscience, 2017 - Elsevier
The effects of endogenous opioid peptide antagonists on panic-related responses are
controversial. Using elevated mazes and a prey-versus-predator paradigm, we investigated …