[HTML][HTML] Design of therapeutic biomaterials to control inflammation

Z Tu, Y Zhong, H Hu, D Shao, R Haag… - Nature Reviews …, 2022 - nature.com
Inflammation plays an important role in the response to danger signals arising from damage
to our body and in restoring homeostasis. Dysregulated inflammatory responses occur in …

The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives

R Sun, J Xiang, Q Zhou, Y Piao, J Tang, S Shao… - Advanced Drug Delivery …, 2022 - Elsevier
Over the past three decades, the enhanced permeability and retention (EPR) effect has
been considered the basis of tumor-targeted drug delivery. Various cancer nanomedicines …

Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance

M Xu, Y Qi, G Liu, Y Song, X Jiang, B Du - ACS nano, 2023 - ACS Publications
Understanding the in vivo transport of nanoparticles provides guidelines for designing
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …

Chemical and biophysical signatures of the protein corona in nanomedicine

J Ren, N Andrikopoulos, K Velonia… - Journal of the …, 2022 - ACS Publications
An inconvenient hurdle in the practice of nanomedicine is the protein corona, a spontaneous
collection of biomolecular species by nanoparticles in living systems. The protein corona is …

Tumor abnormality-oriented nanomedicine design

Q Zhou, J Xiang, N Qiu, Y Wang, Y Piao, S Shao… - Chemical …, 2023 - ACS Publications
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Stimuli‐responsive nanoparticles for controlled drug delivery in synergistic cancer immunotherapy

J Zhang, Y Lin, Z Lin, Q Wei, J Qian, R Ruan… - Advanced …, 2022 - Wiley Online Library
Cancer immunotherapy has achieved promising clinical progress over the recent years for
its potential to treat metastatic tumors and inhibit their recurrences effectively. However, low …

Near-infrared photoactivated nanomedicines for photothermal synergistic cancer therapy

H Sun, Q Zhang, J Li, S Peng, X Wang, R Cai - Nano Today, 2021 - Elsevier
Cancer nanomedicines have provided promising treatment strategies for the regression of
several types of cancer, although there still exists a need for significant advances to improve …

[HTML][HTML] Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy

SB Fournier, JN D'Errico, DS Adler, S Kollontzi… - Particle and Fibre …, 2020 - Springer
Abstract Background Plastic is everywhere. It is used in food packaging, storage containers,
electronics, furniture, clothing, and common single-use disposable items. Microplastic and …

[HTML][HTML] Engineering tumoral vascular leakiness with gold nanoparticles

MI Setyawati, Q Wang, N Ni, JK Tee, K Ariga… - Nature …, 2023 - nature.com
Delivering cancer therapeutics to tumors necessitates their escape from the surrounding
blood vessels. Tumor vasculatures are not always sufficiently leaky. Herein, we engineer …

[HTML][HTML] Noncancerous disease-targeting AIEgens

Y Duo, G Luo, W Zhang, R Wang, GG Xiao… - Chemical Society …, 2023 - pubs.rsc.org
Noncancerous diseases include a wide plethora of medical conditions beyond cancer and
are a major cause of mortality around the world. Despite progresses in clinical research …