The role of lipids in cancer progression and metastasis

M Martin-Perez, U Urdiroz-Urricelqui, C Bigas… - Cell metabolism, 2022 - cell.com
Lipids have essential biological functions in the body (eg, providing energy storage, acting
as a signaling molecule, and being a structural component of membranes); however, an …

[HTML][HTML] Metabolic reprogramming of colorectal cancer cells and the microenvironment: implication for therapy

M Nenkov, Y Ma, N Gaßler, Y Chen - International journal of molecular …, 2021 - mdpi.com
Colorectal carcinoma (CRC) is one of the most frequently diagnosed carcinomas and one of
the leading causes of cancer-related death worldwide. Metabolic reprogramming, a hallmark …

[HTML][HTML] The fatty acid receptor CD36 promotes HCC progression through activating Src/PI3K/AKT axis-dependent aerobic glycolysis

X Luo, E Zheng, L Wei, H Zeng, H Qin, X Zhang… - Cell death & …, 2021 - nature.com
Metabolic reprogramming is a new hallmark of cancer but it remains poorly defined in
hepatocellular carcinogenesis (HCC). The fatty acid receptor CD36 is associated with both …

[HTML][HTML] The role of CD36 in cancer progression and its value as a therapeutic target

WW Feng, HT Zuppe, M Kurokawa - Cells, 2023 - mdpi.com
Cluster of differentiation 36 (CD36) is a cell surface scavenger receptor that plays critical
roles in many different types of cancer, notably breast, brain, and ovarian cancers. While it is …

[HTML][HTML] Fatty acids and evolving roles of their proteins in neurological, cardiovascular disorders and cancers

R Mallick, S Basak, AK Duttaroy - Progress in lipid research, 2021 - Elsevier
The dysregulation of fat metabolism is involved in various disorders, including
neurodegenerative, cardiovascular, and cancers. The uptake of long-chain fatty acids …

[HTML][HTML] Role of CD36 in cancer progression, stemness, and targeting

SL Guerrero-Rodríguez, C Mata-Cruz… - Frontiers in Cell and …, 2022 - frontiersin.org
CD36 is highly expressed in diverse tumor types and its expression correlates with
advanced stages, poor prognosis, and reduced survival. In cancer cells, CD36: 1) increases …

CD36: an emerging therapeutic target for cancer and its molecular mechanisms

C Ruan, Y Meng, H Song - Journal of Cancer Research and Clinical …, 2022 - Springer
Tumor cells need to rewire their metabolic pathways to regulate the nutrient uptake and
metabolism to sustain the energy production. Lipids are important components of energy …

[HTML][HTML] Mitochondrial and metabolic alterations in cancer cells

J Di Gregorio, S Petricca, R Iorio, E Toniato… - European journal of cell …, 2022 - Elsevier
Metabolic alterations have been observed in many cancer types. The deregulated
metabolism has thus become an emerging hallmark of the disease, where the metabolism is …

[HTML][HTML] Upregulation of CD36, a fatty acid translocase, promotes colorectal cancer metastasis by increasing MMP28 and decreasing E-cadherin expression

J Drury, PG Rychahou, CO Kelson, ME Geisen, Y Wu… - Cancers, 2022 - mdpi.com
Simple Summary Colorectal cancer is the second leading cause of cancer-related death in
the world. Upregulation of fatty acid metabolism is a hallmark of cancer and recent studies …

[HTML][HTML] Reprogrammed lipid metabolism and the lipid-associated hallmarks of colorectal cancer

T Salita, YH Rustam, D Mouradov, OM Sieber, GE Reid - Cancers, 2022 - mdpi.com
Simple Summary Colorectal cancer (CRC) is the third-most diagnosed cancer and the
second-leading cause of cancer-related deaths worldwide. Limitations in early and accurate …