Neuropathic pain, whose symptoms are characterized by spontaneous and irritation-
induced painful sensations, is a condition that poses a global burden. Numerous …

Damage on one side of the body can also result in pain on the contralateral unaffected side,
called mirror-image pain (MIP). Currently, the mechanisms responsible for the development …

Activation of glial cells and the intracellular ERK signaling pathway plays an important role
in the development and maintenance of neuropathic pain. As well as neurons, glial cell …

Gap junctions are specialized transmembrane channels that allow rapid electrical signalling
and direct intercellular communication for maintenance and coordination of normal cellular …

J. Neurochem.(2010) 115, 505–514. Abstract Activation of extracellular signal‐regulated
kinase (ERK) in spinal cord neurons could serve as a marker for sensitization of dorsal horn …

A growing body of evidence indicates that prenatal alcohol exposure (PAE) may predispose
individuals to secondary medical disabilities later in life. Animal models of PAE reveal …

Increased sensitivity contralateral to an injury has been described in humans and in various
models of neuropathic pain in rats. The mechanism underlying contralateral hypersensitivity …

Highlights•Brain glial activation is observed in patients suffering from chronic low back
pain.•Microglia maintain a dynamic relationship with neurons.•Astrocytic connexin …

We have previously shown using a spinal cord injury (SCI) model that gap junctions
contribute to the early spread of astrocyte activation in the lumbar spinal cord and that this …

Cerebral activation in response to sequences of temperature boosts at the hindpaw was
observed in functional magnetic resonance imaging (fMRI) experiments in isoflurane …