Fuelled by innovation, optical microscopy plays a critical role in the life sciences and
medicine, from basic discovery to clinical diagnostics. However, optical microscopy is limited …

Atherosclerotic cardiovascular disease results in> 19 million deaths annually, and coronary
heart disease accounts for the majority of this toll. Despite major advances in treatment of …

Importance Pericoronary adipose tissue (PCAT) computed tomography (CT) attenuation
measured from coronary CT angiography (CTA) may be a promising metric in identifying …

Background Experimental studies suggest that low wall shear stress (WSS) promotes
plaque development and high WSS is associated with plaque destabilization. We …

Optical coherence tomography (OCT) is a novel intravascular imaging modality, based on
infrared light emission, that enables a high resolution arterial wall imaging, in the range of …

The paradigm of using nanoparticulate pharmaceutical carriers has been well established
over the past decade, both in pharmaceutical research and in the clinical setting. Drug …

Background Bioabsorbable vascular scaffolds were developed to overcome limitations of
permanent bare-metal or drug-eluting coronary stents—ie, stent thrombosis (despite …

Percutaneous coronary intervention with stenting is the most widely performed procedure for
the treatment of symptomatic coronary disease, and drug-eluting stents (DES) have …

Background Drug-eluting metallic coronary stents predispose to late stent thrombosis,
prevent late lumen vessel enlargement, hinder surgical revascularisation, and impair …

Background A fully bioabsorbable drug-eluting coronary stent that scaffolds the vessel wall
when needed and then disappears once the acute recoil and constrictive remodelling …