Periodontal disease is one of the most common diseases of the oral cavity affecting up to
90% of the worldwide population. Smoking has been identified as a major risk factor in the …

Osteosarcoma is the most frequent type of bone cancer found in children and adolescents,
and commonly arises in the metaphyseal region of tubular long bones. Standard therapeutic …

Background Signal-regulatory protein α (SIRPα) is an essential signaling molecule that
modulates leukocyte inflammatory responses. However, the regulation of selective SIRPα …

Background/Aims: Osteosarcoma is a malignant tumor associated with high mortality;
however, no effective therapies for the disease have been developed. Several studies have …

Meaningful, reliable and valid mRNA expression analyses by real-time quantitative PCR (RT-
qPCR) can only be achieved, if suitable reference genes are chosen for normalization and if …

Background: smoking is considered the most modifiable risk factor for periodontal disease.
Objective: the aim of this narrative review is to emphasize the effect of smoking on …

Periodontal diseases are a range of polymicrobial infectious disorders, such as gingivitis
and periodontitis, which affect tooth‐supporting tissues and are linked to playing a role in the …

Hypoxia (ie oxygen deprivation) activates the hypoxia‐signalling pathway, primarily via
hypoxia‐inducible transcription factors (HIF) for numerous target genes, which mediate …

Objectives A systematic review was conducted to evaluate the in vitro effects of nicotine on
human gingival, periodontal ligament and oral epithelial cells, specifically: cell viability, cell …

Regenerative and translational dentistry marks a shift in the paradigm of endodontic and
periodontic therapy from simple pulp capping and root planning to dental tissue …