The transfer of genetic information into mouse embryos to stably alter the genetic
constitution of mice is affording new insights into and opportunities in a wide variety of …

Publisher Summary Although some T cell differentiation can occur outside the thymus, by far
majority of the T cells develop within the thymus, and this chapter discusses the intrathymic …

Among the universe of vertebrate receptors, the family of antigen-specific receptors on
lymphocytes is unique in its requirement to discriminate between ligands that are self and …

T cells become tolerant of self antigens during their development in the thymus. Clonal
deletion of thymocytes bearing self-reactive T cell receptors is a major mechanism for …

Thymic dendritic cells (DCs) as well as thymic epithelial cells are presumed to be major
sentinels in central tolerance by inducing the apoptosis of autoreactive T progenitor cells …

The recognition of virus-infected cells by class I MHC-restricted cytotoxic T cells requires
endogenous processing of antigen for presentation. It is still unclear whether endogenous …

TOLERANCE to self-antigens has been shown to develop during ontogeny as a result of the
elonal deletion of self-reactive T cells1–4. Tolerance, or better'nonresponsiveness', to …

Autoimmune diabetes is the clinical end point for a sequential cascade of immunologic
events that occur in a genetically susceptible individual. Structural and functional analysis of …

LEW (RT1l) rats were immunized with peptides corresponding to the alpha helical region of
the alpha 1 domain (peptide 1), the beta sheet of the alpha 2 domain (peptide 2), and the …

Dendritic cells (DCs) are thought to be responsible for sensitization to inhaled Ag and
induction of adaptive immunity in the lung. The characteristics of T cell activation in the lung …