The MHC-self immunopeptidome of professional antigen presenting cells is a cognate
ligand for the TCRs expressed on both conventional and thymic-derived natural regulatory T …

The ability of CD8+ T cells to engage a diverse range of peptide–major histocompatibility
complex (MHC) complexes can also lead to cross-recognition of self and nonself peptide …

Most immature CD4+ CD8+ thymocytes express only a small number of T cell receptor
(TCR) molecules on their surface, and the TCR molecules they do express are only …

The present study was performed to identify cells responsible for the elimination of T cells
reactive with minor lymphocyte-stimulating (Mls) antigens during T cell development …

Induction of mixed chimerism has the potential to overcome the current limitations of
transplantation, namely chronic rejection, complications of immunosuppressive therapy and …

Publisher Summary It was recognized that in most cases the antigen is processed by the
antigen-presenting cells (APC), such that the fragments of antigen, rather than antigen per …

To study the nature of tolerance to antigens not expressed by cells of the lymphoid system,
expression of class II MHC IE was targeted to the acinar cells of the exocrine pancreas in …

The successful transduction of hematopoietic stem cells and long-term (28 months)
transgene expression within the hematopoietic system following the direct injection of high …

Antigen presentation is a critical step in the activation of naïve T lymphocytes. In mammals,
dendritic cells (DCs), macrophages, and B lymphocytes can all function as antigen …

Transgenic mice with defined expression of major histocompatibility complex (MHC)
proteins provide novel systems for understanding the fundamental question of T cell …