Intramyocellular lipid (IMCL) is predominantly stored as intramuscular triglyceride (IMTG) in
lipid droplets and is utilized as metabolic fuel during physical exercise. IMTG is also …

High‐intensity interval training (HIT) is known to increase mitochondrial content in a similar
way as endurance training [60–90% of maximal oxygen uptake (VO 2peak)]. Whether HIT …

Introduction: Obesity and type 2 diabetes are growing health problems worldwide. The three
principal diabetogenic factors are adiposity, insulin resistance in skeletal muscle, and …

Obesity increases the risk of metabolic diseases, including insulin resistance and type 2
diabetes, as well as cardiovascular disease. In addition to lipid accumulation in adipose …

Fatty acids (FAs) are essential elements of all cells and have significant roles as energy
substrates, components of cellular structure and signalling molecules. The storage of excess …

Understanding the factors that contribute to exercise response variation is the first step in
achieving the goal of developing personalized exercise prescriptions. This review discusses …

Disturbances in fatty acid metabolism in adipose tissue, liver, skeletal muscle, gut and
pancreas play an important role in the development of insulin resistance, impaired glucose …

BACKGROUND. Accumulation of diacylglycerol (DAG) and sphingolipids is thought to
promote skeletal muscle insulin resistance by altering cellular signaling specific to their …

Both Roux-en-Y gastric bypass (RYGB) surgery and exercise can improve insulin sensitivity
in individuals with severe obesity. However, the impact of RYGB with or without exercise on …

Key points Increases in aerobic capacity and intramuscular triglyceride (IMTG) utilization are
well‐described adaptations to endurance training (ET) and contribute to improvements in …