SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

VJ Costela-Ruiz, R Illescas-Montes… - Cytokine & growth factor …, 2020 - Elsevier
COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of
physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly …

The paradoxical role of IL-10 in immunity and cancer

MH Mannino, Z Zhu, H Xiao, Q Bai, MR Wakefield… - Cancer letters, 2015 - Elsevier
Abstract Interleukin-10 (IL-10) produced by a wide-variety of cells is a highly pleiotropic
cytokine. It has been implicated in the pathogenesis and/or development of autoimmune …

Interleukin-10 and the interleukin-10 receptor

KW Moore, R de Waal Malefyt… - Annual review of …, 2001 - annualreviews.org
Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of
T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on …

Interleukin‐10: new perspectives on an old cytokine

DM Mosser, X Zhang - Immunological reviews, 2008 - Wiley Online Library
Interleukin‐10 (IL‐10) has long been recognized to have potent and broad‐spectrum anti‐
inflammatory activity, which has been unequivocally established in various models of …

[HTML][HTML] Interleukin-10 directly inhibits CD8+ T cell function by enhancing N-glycan branching to decrease antigen sensitivity

LK Smith, GM Boukhaled, SA Condotta, S Mazouz… - Immunity, 2018 - cell.com
Chronic viral infections remain a global health concern. The early events that facilitate viral
persistence have been linked to the activity of the immunoregulatory cytokine IL-10 …

Interleukin-10 therapy—review of a new approach

K Asadullah, W Sterry, HD Volk - Pharmacological reviews, 2003 - ASPET
Interleukin (IL)-10 is an important immunoregulatory cytokine produced by many cell
populations. Its main biological function seems to be the limitation and termination of …

Current status of interleukin-10 and regulatory T-cells in cancer

KL Dennis, NR Blatner, F Gounari… - Current opinion in …, 2013 - journals.lww.com
Current status of interleukin-10 and regulatory T-cells in c... : Current Opinion in Oncology
Current status of interleukin-10 and regulatory T-cells in cancer : Current Opinion in …

IL-10 Directly Activates and Expands Tumor-Resident CD8+ T Cells without De Novo Infiltration from Secondary Lymphoid Organs

J Emmerich, JB Mumm, IH Chan, D LaFace, H Truong… - Cancer research, 2012 - AACR
The presence of activated intratumoral T cells correlates clinically with better prognosis in
patients with cancer. Although tumor vaccines can increase the number of tumor-specific …

[PDF][PDF] Pro-versus anti-inflammatory cytokines: myth or reality

JM Cavaillon - Cellular And Molecular Biology-Paris-Wegmann-, 2001 - researchgate.net
Inflammation is characterized by an interplay between pro-and anti-inflammatory cytokines.
Cytokines are commonly classified in one or the other category: interleukin-1 (IL-1), tumor …

The dual role of IL-10

S Mocellin, MC Panelli, E Wang, D Nagorsen… - Trends in …, 2003 - cell.com
Classification of cytokines as pro-versus anti-inflammatory might not apply to the pleiotropic
effects of interleukin-10 (IL-10). Several reports suggest that IL-10 enhances the function of …