Although immunotherapy research to date has focused largely on T cells, there is mounting
evidence that tumour-infiltrating B cells and plasma cells (collectively referred to as tumour …

▪ Abstract Neutralizing antiviral B cell responses differ in various aspects from the many
usually measured B cell responses specific for protein in adjuvants. In particular, such …

Autoimmune diseases are thought to be initiated by exposures to foreign antigens that cross-
react with endogenous molecules. Scleroderma is an autoimmune connective tissue …

Systemic lupus erythematosus is a multisystem autoimmune disease in which the
autoantibody response targets a variety of autoantigens of diverse subcellular location. We …

Experimental autoimmune encephalomyelitis (EAE) is an animal model for autoimmune
central nervous system disease mediated by CD4 T cells. To examine the role of B cells in …

I present here a new model for the primary activation of precursor helper T cells.
Observations demonstrate that the immune system learns not to respond to extrathymic …

The precise role of B cells in systemic autoimmunity is incompletely understood. Although B
cells are necessary for expression of disease (Chan, O., and MJ Shlomchik. 1998. J …

Systemic lupus erythematosus, a prototypical systemic autoimmune disease, is the result of
a series of interactions within the immune system that ultimately lead to the loss of self …

In this review, we first consider the inherent structural constraints for binding of a peptide to
MHC class II molecules. Such parameters at the site of TCR recognition are dependent upon …

Purified CD4+ lymph node T cells were sorted into two populations on the basis of their
expression of CD45RB (CD45RBhi and CD45RBlo) and injected into congenic severe …