The progressive increase in lifespan over the past century carries with it some adversity
related to the accompanying burden of debilitating diseases prevalent in the older …

The evolutionary theory of ageing explains why ageing occurs, giving valuable insight into
the mechanisms underlying the complex cellular and molecular changes that contribute to …

Gut bacteria occupy the interface between the organism and the external environment,
contributing to homeostasis and disease. Yet, the causal role of the gut microbiota during …

The main objective of this review is to examine the role of endogenous reactive
oxygen/nitrogen species (ROS) in the aging process. Until relatively recently, ROS were …

Mutations in genes affecting endocrine signaling, stress responses, metabolism, and
telomeres can all increase the life spans of model organisms. These mutations have …

To explore the role of mitochondrial activity in the aging process, we have lowered the
activity of the electron transport chain and adenosine 5′-triphosphate (ATP) synthase with …

Maximum life span differences among animal species exceed life span variation achieved
by experimental manipulation by orders of magnitude. The differences in the characteristic …

Searches for genes involved in the ageing process have been made in genetically tractable
model organisms such as yeast, the nematode Caenorhabditis elegans, Drosophila …

Bigger animals live longer. The scaling exponent for the relationship between lifespan and
body mass is between 0.15 and 0.3. Bigger animals also expend more energy, and the …

What molecular processes drive cell aging and death? Here, we model how proteostasis—
ie, the folding, chaperoning, and maintenance of protein function—collapses with age from …