We have previously reported CLIC5A and SLC12A2 variants in two families from Cameroon
and Ghana, segregating non-syndromic hearing impairment (NSHI). In this study, biological …

SIX1 homeodomain protein is one of the essential key regulators of sensory organ
development. Six1-deficient mice lack the olfactory epithelium, vomeronasal organs …

Background: Emerging evidence indicates that the sineoculis homeobox homolog 1− eyes
absent homolog 1 (SIX1–EYA1) transcriptional complex significantly contributes to the …

Motivation: Transcription factor interactions are the cornerstone of combinatorial control,
which is a crucial aspect of the gene regulatory system. Understanding and predicting …

To examine the effect of Clusterin (CLU) on mastitis, genetic association analysis was
applied on mastitis and milk production traits of 1,137 Chinese Holstein cows. We detected …

During development cells of epithelial and mesenchymal origin convert between the two
phenotypes in what has been described as Epithelial-Mesenchymal Transition (EMT) and …

Six1, which belongs to the sine oculis homeobox (Six) protein family, is an evolutionarily
conserved transcription factor found in diverse organisms ranging from flatworms to humans …

Myogenesis or muscle development begins with cell cycle arrest and continues with a
differentiation program that converts myoblasts into multi-nucleated cells referred to as …

The developed pituitary gland comprises of three lobes: the anterior, the intermediate and
the posterior lobe. The anterior and intermediate lobes derive from an invagination of the …

Six1 and Eya1 are known to play central roles in the development of placodes from the
preplacodal ectoderm (PPE) but little is currently known about the target genes that mediate …