Normal cells explore multiple states to survive stresses encountered during development
and self-renewal as well as environmental stresses such as starvation, DNA damage, toxins …

Cancer cells establish replicative immortality by activating a telomere-maintenance
mechanism (TMM), be it telomerase or the alternative lengthening of telomeres (ALT) …

Molecular alterations in cancer genes and associated signaling pathways are used to inform
new treatments for precision medicine in cancer. Small molecule inhibitors and monoclonal …

Simple Summary Internationally, in women, breast cancer (BC) is the most common cancer
type and is the leading cause of cancer-related death. There are two main histological …

Continuous cell division is a hallmark of cancer, and the underlying mechanism is tumor
genomics instability. Cell cycle checkpoints are critical for enabling an orderly cell cycle and …

AZD6738 (ceralasertib) is a potent and selective orally bioavailable inhibitor of ataxia
telangiectasia and Rad3-related (ATR) kinase. ATR is activated in response to stalled DNA …

Poly (ADP-ribose) polymerase inhibitors (PARPi) are a unique class of antineoplastic agents
that function by inducing synthetic lethality. Synthetic lethality occurs when PARPi and either …

Ataxia telangiectasia and Rad3-related (ATR) kinase protects genome integrity during DNA
replication. RP-3500 is a novel, orally bioavailable clinical-stage ATR kinase inhibitor …

The correct duplication and transfer of genetic material to daughter cells is the major event of
cell division. Dysfunction of DNA replication or chromosome segregation presents …

Steroid hormone signaling induces vast gene expression programs which necessitate the
local formation of transcription factories at regulatory regions and large-scale alterations of …