In the last 20 years, surface plasmon resonance (SPR) and its advancement with imaging
(SPRi) emerged as a suitable and reliable platform in clinical analysis for label-free …

Abstract ATP Binding Cassette (ABC) transporters, widely studied in cancer for their role in
drug resistance, have been more recently also considered for their contribution to cancer …

ATP-binding cassette (ABC) transporters mediate multidrug resistance in cancer. In contrast
to DNA single nucleotide polymorphisms in normal tissues, the role of mutations in tumors is …

Background: MDR1, one of the most important drug-transporter genes, encodes P-
glycoprotein (P-gp)-a transporter involved in protecting against xenobiotics and multi-drug …

Purpose Genetic variants of ABCB1 gene contributed to cancer susceptibility and
interindividual differences in chemotherapy response. Therefore, we investigated the …

Background: Breast cancer is the leading cause of cancer death among women and the
second in humans worldwide. Many published studies have suggested an association …

Background The ATP-binding cassette transporter B1 (ABCB1) gene codes for a membrane
efflux pump localized in epithelial cells. Together with other Permeability-glycoproteins in …

Background Breast cancer is the most common cause of cancer death among women.
Several studies have investigated the relationship between the C3435T polymorphism of …

Background: Acute lymphoblastic leukemia (ALL) is a complex disease caused by
interactions between hazardous exogenous or/and endogenous agents and many mild …

Abstract The C3435T (rs1045642) polymorphism, located in multi-drug resistance gene 1
(MDR1), has demonstrated its role in decreasing the P-gp activity level which is related to …