[HTML][HTML] Delivery of biologics: Topical administration
Biologics are unaffordable to a large majority of the global population because of
prohibitively expensive fermentation systems, purification and the requirement for cold chain …
prohibitively expensive fermentation systems, purification and the requirement for cold chain …
Rational designs of biomaterials for combating oral biofilm infections
Z Yin, Y Liu, A Anniwaer, Y You, J Guo… - Advanced …, 2023 - Wiley Online Library
Oral biofilms, which are also known as dental plaque, are the culprit of a wide range of oral
diseases and systemic diseases, thus contributing to serious health risks. The manner of …
diseases and systemic diseases, thus contributing to serious health risks. The manner of …
A targeted exosome therapeutic confers both CfDNA scavenging and macrophage polarization for ameliorating rheumatoid arthritis
Z Wang, C Zhang, J Meng, Z Jiao, W Bao… - Advanced …, 2023 - Wiley Online Library
Only a minority of rheumatoid arthritis (RA) patients achieve disease remission, so the
exploration of additional pathogenic factors and the development of new therapeutics are …
exploration of additional pathogenic factors and the development of new therapeutics are …
Lepr‐expressing PDLSCs contribute to periodontal homeostasis and respond to mechanical force by Piezo1
Periodontium supports teeth in a mechanically stimulated tissue environment, where
heterogenous stem/progenitor populations contribute to periodontal homeostasis. In this …
heterogenous stem/progenitor populations contribute to periodontal homeostasis. In this …
Triple Cross‐linked Dynamic Responsive Hydrogel Loaded with Selenium Nanoparticles for Modulating the Inflammatory Microenvironment via PI3K/Akt/NF‐κB and …
S Wang, Y Liu, Q Sun, B Zeng, C Liu, L Gong… - Advanced …, 2023 - Wiley Online Library
Modulating the inflammatory microenvironment can inhibit the process of inflammatory
diseases (IDs). A tri‐cross‐linked inflammatory microenvironment‐responsive hydrogel with …
diseases (IDs). A tri‐cross‐linked inflammatory microenvironment‐responsive hydrogel with …
[HTML][HTML] Multifunctional dendrimer@ nanoceria engineered GelMA hydrogel accelerates bone regeneration through orchestrated cellular responses
Bone defects in patients entail the microenvironment that needs to boost the functions of
stem cells (eg, proliferation, migration, and differentiation) while alleviating severe …
stem cells (eg, proliferation, migration, and differentiation) while alleviating severe …
A telluroviologen-anchored tetraphenylporphyrin as sonosensitizer for periodontitis sonodynamic therapy
Q Sun, W Song, Y Gao, R Ding, S Shi, S Han, G Li… - Biomaterials, 2024 - Elsevier
Periodontitis is a chronic disease caused by bacteria (eg Porphyromonas gingivalis, P.
gingivalis) that currently lacks effective non-invasive treatment options. Sonodynamic …
gingivalis) that currently lacks effective non-invasive treatment options. Sonodynamic …
Bio-functional immunomodulatory europium-doped hydroxyapatite nanorods for osteochondral repair via CDH5-RAS-RAF-MEK-ERK-CSF1 axis
Y Jin, M Shu, Z Liu, H Li, C Liu, C Zhu, Z Zhu… - Chemical Engineering …, 2024 - Elsevier
Osteoarthritis (OA) remains an unsolved clinical problem characterized by cartilage
degradation and subchondral bone remodeling. Most studies have focused on cartilage …
degradation and subchondral bone remodeling. Most studies have focused on cartilage …
[HTML][HTML] Impact of circulating cell-free DNA (cfDNA) as a biomarker of the development and evolution of periodontitis
In the last few decades, circulating cell-free DNA (cfDNA) has been shown to have an
important role in cell apoptosis or necrosis, including in the development and evolution of …
important role in cell apoptosis or necrosis, including in the development and evolution of …
Design and fabrication of intracellular therapeutic cargo delivery systems based on nanomaterials: current status and future perspectives
H Ma, F Xing, Y Zhou, P Yu, R Luo, J Xu… - Journal of Materials …, 2023 - pubs.rsc.org
Intracellular cargo delivery, the introduction of small molecules, proteins, and nucleic acids
into a specific targeted site in a biological system, is an important strategy for deciphering …
into a specific targeted site in a biological system, is an important strategy for deciphering …