[HTML][HTML] Delivery of biologics: Topical administration

RJ Kulchar, R Singh, S Ding, E Alexander, KW Leong… - Biomaterials, 2023 - Elsevier
Biologics are unaffordable to a large majority of the global population because of
prohibitively expensive fermentation systems, purification and the requirement for cold chain …

Rational designs of biomaterials for combating oral biofilm infections

Z Yin, Y Liu, A Anniwaer, Y You, J Guo… - Advanced …, 2023 - Wiley Online Library
Oral biofilms, which are also known as dental plaque, are the culprit of a wide range of oral
diseases and systemic diseases, thus contributing to serious health risks. The manner of …

A targeted exosome therapeutic confers both CfDNA scavenging and macrophage polarization for ameliorating rheumatoid arthritis

Z Wang, C Zhang, J Meng, Z Jiao, W Bao… - Advanced …, 2023 - Wiley Online Library
Only a minority of rheumatoid arthritis (RA) patients achieve disease remission, so the
exploration of additional pathogenic factors and the development of new therapeutics are …

Lepr‐expressing PDLSCs contribute to periodontal homeostasis and respond to mechanical force by Piezo1

D Zhang, W Lin, S Jiang, P Deng, L Liu… - Advanced …, 2023 - Wiley Online Library
Periodontium supports teeth in a mechanically stimulated tissue environment, where
heterogenous stem/progenitor populations contribute to periodontal homeostasis. In this …

Triple Cross‐linked Dynamic Responsive Hydrogel Loaded with Selenium Nanoparticles for Modulating the Inflammatory Microenvironment via PI3K/Akt/NF‐κB and …

S Wang, Y Liu, Q Sun, B Zeng, C Liu, L Gong… - Advanced …, 2023 - Wiley Online Library
Modulating the inflammatory microenvironment can inhibit the process of inflammatory
diseases (IDs). A tri‐cross‐linked inflammatory microenvironment‐responsive hydrogel with …

[HTML][HTML] Multifunctional dendrimer@ nanoceria engineered GelMA hydrogel accelerates bone regeneration through orchestrated cellular responses

AG Kurian, N Mandakhbayar, RK Singh, JH Lee… - Materials Today Bio, 2023 - Elsevier
Bone defects in patients entail the microenvironment that needs to boost the functions of
stem cells (eg, proliferation, migration, and differentiation) while alleviating severe …

A telluroviologen-anchored tetraphenylporphyrin as sonosensitizer for periodontitis sonodynamic therapy

Q Sun, W Song, Y Gao, R Ding, S Shi, S Han, G Li… - Biomaterials, 2024 - Elsevier
Periodontitis is a chronic disease caused by bacteria (eg Porphyromonas gingivalis, P.
gingivalis) that currently lacks effective non-invasive treatment options. Sonodynamic …

Bio-functional immunomodulatory europium-doped hydroxyapatite nanorods for osteochondral repair via CDH5-RAS-RAF-MEK-ERK-CSF1 axis

Y Jin, M Shu, Z Liu, H Li, C Liu, C Zhu, Z Zhu… - Chemical Engineering …, 2024 - Elsevier
Osteoarthritis (OA) remains an unsolved clinical problem characterized by cartilage
degradation and subchondral bone remodeling. Most studies have focused on cartilage …

[HTML][HTML] Impact of circulating cell-free DNA (cfDNA) as a biomarker of the development and evolution of periodontitis

G Viglianisi, S Santonocito, A Polizzi, G Troiano… - International Journal of …, 2023 - mdpi.com
In the last few decades, circulating cell-free DNA (cfDNA) has been shown to have an
important role in cell apoptosis or necrosis, including in the development and evolution of …

Design and fabrication of intracellular therapeutic cargo delivery systems based on nanomaterials: current status and future perspectives

H Ma, F Xing, Y Zhou, P Yu, R Luo, J Xu… - Journal of Materials …, 2023 - pubs.rsc.org
Intracellular cargo delivery, the introduction of small molecules, proteins, and nucleic acids
into a specific targeted site in a biological system, is an important strategy for deciphering …