Parkinson's disease (PD) is the second leading neurodegenerative disease globally,
impacting the quality of life of millions of people. It is estimated that the treatment cost of PD …

Modeling and simulation of oral drug absorption have been widely used in drug discovery,
development, and regulation. Predictive absorption models are used to determine the rate …

Controlled Drug Delivery Page 1 Controlled Drug Delivery Page 2 DRUGS AND THE
PHARMACEUTICAL SCIENCES A Series of Textbooks and Monographs Edited by James …

Hysteresis loops are phenomena that sometimes are encountered in the analysis of
pharmacokinetic and pharmacodynamic relationships spanning from pre-clinical to clinical …

The absorption of 111 drug and drug-like compounds was evaluated from 111 references
based on the ratio of urinary excretion of drugs following oral and intravenous administration …

Fescue alkaloid intake by cattle results in adverse metabolic effects that cause billion dollar
losses annually to livestock production in the US alone (Bacon et al., 1977; Garner and …

Bromocriptine, a potent dopamine D 2 receptor agonist, suppresses lipogenesis and
improves glucose intolerance and insulin resistance. Recent evidence suggests that …

Bromocriptin (BCT) is a dopaminergic receptor agonist, poorly transported through the blood–
brain barrier (BBB) and responsible for central side effects. Interactions between BCT and …

Conception, pregnancy, and childbirth are complex processes that affect both mother and
fetus. Thus, it is perhaps not surprising that in the United States alone, roughly 11% of …

With the intention of compensating for the deficit of endogenous dopamine (DA) in the basal
ganglia of Parkinsonian patients by substitution with agents which directly stimulate central …