This review presents the changes that the imaging of articular cartilage has undergone
throughout the last decades. It highlights that the expectation is no longer to image the …

Successful organ or tissue long-term preservation would revolutionize biomedicine.
Cartilage cryopreservation enables prolonged shelf life of articular cartilage, posing the …

Chondrocyte viability is a crucial factor in evaluating cartilage health. Most cell viability
assays rely on dyes and are not applicable for in vivo or longitudinal studies. We previously …

Detecting articular cartilage (AC) degeneration in its early stage plays a critical role in the
diagnosis and treatment of osteoarthritis (OA). Polarization-sensitive optical coherence …

Objective There is little knowledge about the histological organization of facial and costal
cartilages in terms of matrix structure and cell morphology. Second harmonic generation …

Objective Chondrocyte viability (CV) can be measured with the label-free method using
second harmonic generation (SHG) and two-photon excitation autofluorescence (TPAF) …

Establishing quantitative parameters for differentiating between healthy and diseased
cartilage tissues by examining collagen fibril degradation patterns facilitates the …

Tissue preparation for histologic evaluation of bone is particularly lengthy, limiting its use in
intraoperative or intraprocedural histological evaluation. Nonlinear microscopy (NLM) is an …

Chondrocyte viability is an important measure to consider when assessing cartilage health.
Dye-based cell viability assays are not suitable for in vivo or long-term studies. We have …

Biomedical optical imaging technologies are playing an indispensable role in basic
research and clinical diagnosis owing to their superior spatial resolution, rich imaging …