What are 3′ UTRs doing?
C Mayr - Cold Spring Harbor perspectives in biology, 2019 - cshperspectives.cshlp.org
SUMMARY 3′ untranslated regions (3′ UTRs) of messenger RNAs (mRNAs) are best
known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and …
known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and …
Alternative polyadenylation of mRNA precursors
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
[HTML][HTML] Widespread shortening of 3′ UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells
In cancer cells, genetic alterations can activate proto-oncogenes, thereby contributing to
tumorigenesis. However, the protein products of oncogenes are sometimes overexpressed …
tumorigenesis. However, the protein products of oncogenes are sometimes overexpressed …
[HTML][HTML] Ending the message: poly (A) signals then and now
NJ Proudfoot - Genes & development, 2011 - genesdev.cshlp.org
Abstract Polyadenylation [poly (A)] signals (PAS) are a defining feature of eukaryotic protein-
coding genes. The central sequence motif AAUAAA was identified in the mid-1970s and …
coding genes. The central sequence motif AAUAAA was identified in the mid-1970s and …
HITS-CLIP yields genome-wide insights into brain alternative RNA processing
Protein–RNA interactions have critical roles in all aspects of gene expression. However,
applying biochemical methods to understand such interactions in living tissues has been …
applying biochemical methods to understand such interactions in living tissues has been …
Proliferating cells express mRNAs with shortened 3'untranslated regions and fewer microRNA target sites
R Sandberg, JR Neilson, A Sarma, PA Sharp… - Science, 2008 - science.org
Messenger RNA (mRNA) stability, localization, and translation are largely determined by
sequences in the 3′ untranslated region (3′ UTR). We found a conserved increase in …
sequences in the 3′ untranslated region (3′ UTR). We found a conserved increase in …
CPSF30-L-mediated recognition of mRNA m6A modification controls alternative polyadenylation of nitrate signaling-related gene transcripts in Arabidopsis
Abstract N 6-methyladenosine (m 6 A), a ubiquitous internal modification of eukaryotic
mRNAs, plays a vital role in almost every aspect of mRNA metabolism. However, there is …
mRNAs, plays a vital role in almost every aspect of mRNA metabolism. However, there is …
[HTML][HTML] U1 snRNP determines mRNA length and regulates isoform expression
Summary U1 snRNP (U1), in addition to its splicing role, protects pre-mRNAs from drastic
premature termination by cleavage and polyadenylation (PCPA) at cryptic polyadenylation …
premature termination by cleavage and polyadenylation (PCPA) at cryptic polyadenylation …
The role of the 3'untranslated region in post-transcriptional regulation of protein expression in mammalian cells.
E Matoulkova, E Michalova, B Vojtesek, R Hrstka - RNA biology, 2012 - Taylor & Francis
The untranslated regions (UTRs) at the 3'end of mRNA transcripts contain important
sequences that influence the fate of mRNA and thus proteosynthesis. In this review, we …
sequences that influence the fate of mRNA and thus proteosynthesis. In this review, we …
A large-scale analysis of mRNA polyadenylation of human and mouse genes
B Tian, J Hu, H Zhang, CS Lutz - Nucleic acids research, 2005 - academic.oup.com
Abstract mRNA polyadenylation is a critical cellular process in eukaryotes. It involves 3′
end cleavage of nascent mRNAs and addition of the poly (A) tail, which plays important roles …
end cleavage of nascent mRNAs and addition of the poly (A) tail, which plays important roles …