Genetic susceptibility to multiple sclerosis is associated with genes of the major
histocompatibility complex (MHC), particularly HLA-DRB1 and HLA-DQB1 (ref.). Both locus …

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
characterized by focal demyelination patches associated with inflammatory infiltrates …

To provide a definitive linkage map for multiple sclerosis, we have genotyped the Illumina
BeadArray linkage mapping panel (version 4) in a data set of 730 multiplex families of …

Multiple sclerosis afflicts more than 1 million individuals worldwide and is widely considered
to be an autoimmune disease. Traditionally, CD4+ T helper cells have almost exclusively …

Traditionally, autoimmune pathogeneses have been attributed to CD4+ T lymphocytes, as in
multiple sclerosis (MS), rheumatoid arthritis, type 1 diabetes mellitus, and/or to B …

An association between multiple sclerosis (MS) and the human leukocyte antigen (HLA)
complex, a dense cluster of genes on the short arm of chromosome 6, was first noted over …

Autoimmune, inflammatory, and infectious diseases present a major burden to human health
and are frequently associated with loci in the human major histocompatibility complex …

A recent high-density linkage screen confirmed that the HLA complex contains the strongest
genetic factor for the risk of multiple sclerosis (MS). In parallel, a linkage disequilibrium …

Autoimmune diseases are the result of an interplay between predisposing genes and
triggering environmental factors, leading to loss of self-tolerance and an immune-mediated …

The major known genetic risk factors in multiple sclerosis reside in the major
histocompatibility complex (MHC) region. Although there is strong evidence implicating …