ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases
C Alvarez-Navarro, JAL de Castro - Molecular immunology, 2014 - Elsevier
The endoplasmic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme involved
in the final processing of Major Histocompatibility Complex class I (MHC-I) ligands and with …
in the final processing of Major Histocompatibility Complex class I (MHC-I) ligands and with …
CD8+ T Cell-mediated mechanisms contribute to the progression of neurocognitive impairment in both multiple sclerosis and Alzheimer's disease?
Z Stojić-Vukanić, S Hadžibegović, O Nicole… - Frontiers in …, 2020 - frontiersin.org
Neurocognitive impairment (NCI) is one of the most relevant clinical manifestations of
multiple sclerosis (MS). The profile of NCI and the structural and functional changes in the …
multiple sclerosis (MS). The profile of NCI and the structural and functional changes in the …
[HTML][HTML] A tale of two systems: Lessons learned from female mid-life aging with implications for Alzheimer's prevention & treatment
Neurological aging is frequently viewed as a linear process of decline, whereas in reality, it
is a dynamic non-linear process. The dynamic nature of neurological aging is exemplified …
is a dynamic non-linear process. The dynamic nature of neurological aging is exemplified …
[HTML][HTML] Role of CD8 T cell subsets in the pathogenesis of multiple sclerosis
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system
leading to demyelination and axonal/neuronal loss. Cumulating evidence points to a key …
leading to demyelination and axonal/neuronal loss. Cumulating evidence points to a key …
Decreased T cell reactivity to Epstein–Barr virus infected lymphoblastoid cell lines in multiple sclerosis
MP Pender, PA Csurhes, A Lenarczyk… - Journal of Neurology …, 2009 - jnnp.bmj.com
Objective: To investigate T cell and antibody immunity to Epstein–Barr virus (EBV) in
multiple sclerosis (MS). Methods: Immunoglobulin G (IgG) immunity to EBV nuclear antigen …
multiple sclerosis (MS). Methods: Immunoglobulin G (IgG) immunity to EBV nuclear antigen …
[HTML][HTML] Contribution of CD8 T lymphocytes to the immuno-pathogenesis of multiple sclerosis and its animal models
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by multi-focal demyelination, axonal loss, and immune cell infiltration …
characterized by multi-focal demyelination, axonal loss, and immune cell infiltration …
HLA B* 44: protective effects in MS susceptibility and MRI outcome measures
Objective: In addition to the main multiple sclerosis (MS) major histocompatibility complex
(MHC) risk allele (HLA DRB1* 1501), investigations of the MHC have implicated several …
(MHC) risk allele (HLA DRB1* 1501), investigations of the MHC have implicated several …
Marked differences in prevalence of multiple sclerosis between ethnic groups in Oslo, Norway
C Smestad, L Sandvik, T Holmoy, HF Harbo… - Journal of …, 2008 - Springer
Objectives Oslo, the capital of Norway, has a high prevalence of multiple sclerosis (MS). In
recent decades there has been substantial immigration to Oslo from Asia, the Middle East …
recent decades there has been substantial immigration to Oslo from Asia, the Middle East …
[HTML][HTML] Gut microbiome and the risk factors in central nervous system autoimmunity
J Ochoa-Repáraz, LH Kasper - FEBS letters, 2014 - Elsevier
Humans are colonized after birth by microbial organisms that form a heterogeneous
community, collectively termed microbiota. The genomic pool of this macro-community is …
community, collectively termed microbiota. The genomic pool of this macro-community is …
Linkage disequilibrium between human leukocyte antigen (HLA) class II and HLA-G—possible implications for human reproduction and autoimmune disease
TVF Hviid, OB Christiansen - Human immunology, 2005 - Elsevier
A line of investigation indicates that one or several genes in the human major
histocompatibility complex (MHC) influences reproductive success. Studies have revealed …
histocompatibility complex (MHC) influences reproductive success. Studies have revealed …