There is an increasing interest in the intestinal microbiota as a critical regulator of the
development and function of the immune, nervous, and endocrine systems. Experimental …

The human leucocyte antigen (HLA) class II haplotype DRB1* 15–DQB1* 06 (DR15–DQ6) is
associated with susceptibility to multiple sclerosis (MS), and HLA class I associations in MS …

Background In Northern European descended populations, genetic susceptibility for multiple
sclerosis (MS) is associated with alleles of the human leukocyte antigen (HLA) Class II gene …

It was hypothesized that the EBV-specific CD8+ T cell response may be dysregulated in
multiple sclerosis (MS) patients, possibly leading to a suboptimal control of this virus. To …

Patients with multiple sclerosis (MS) display significant peripheral blood CD8+ T cell
receptor biases, suggesting clonal selection. Our objective was to identify relevant myelin …

Objective Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central
nervous system. A human leukocyte antigen (HLA) class II association is well established …

Background: By comparison with the neighboring island of Sicily, the frequency of multiple
sclerosis (MS) in Malta is remarkably low. Methods: To explore whether the relative rarity of …

Multiple sclerosis (MS) is the most common human demyelinating disease of the central
nervous system. It is universally accepted that the immune system plays a major role in the …

The structure of the human major histocompatability (MHC) class I molecule HLA-A* 0301
(HLA-A3) in complex with a nonameric peptide (KLIETYFSK) has been determined by X-ray …

This study is an extension to previously published work that has linked variation in the
human leukocyte antigen (HLA) class I region with susceptibility to multiple sclerosis (MS) in …