Current therapeutics in multiple sclerosis (MS) target the putative inflammation and immune
attack on CNS myelin. Despite their effectiveness in blunting the relapse rate in MS patients …

Background: Pediatric onset multiple sclerosis (MS) accounts for 2-4% of all MS. It is
unknown whether the disease shares the same underlying pathophysiology found in adult …

An increased percentage of blood CD8+ T cells from patients with clinically isolated
syndromes (CIS) suggestive of multiple sclerosis (MS) was found to express CD26 and …

It is now clear that association-based studies in large cohorts will be needed to unravel the
genetic basis of susceptibility to multiple sclerosis. Importantly it is also clear that the …

Several studies suggest that the histocompatibility complex (HLA) class I region harbours
genes modulating multiple sclerosis (MS) susceptibility independently from the effect of …

Detection of gene variants affecting the risk for multiple sclerosis provides insights into
mechanisms central for autoaggressive neuroinflammation. Major histocompatibility …

Chromosome region 2q33 encodes several regulators of the immune system, among these
the CD28, CTLA4, and ICOS molecules. Involvement of these genes in multiple sclerosis …

The main genetic predisposition to type 1 diabetes (T1D) is known to be conferred by the
HLA-DRB1,-DQA1 and-DQB1 genes in the major histocompatibility complex (MHC). Other …

Type 1 diabetes (T1D) is an autoimmune disease that leads to the destruction of the insulin-
producing pancreatic β cells. While there is no current cure, recent work in the field of …

The association of the tumor necrosis factor alpha (TNFα)− G308A promoter polymorphism
with schizophrenia has complemented clinical findings of increased levels of the TNFα …