The development of cholangiopathies after liver transplantation impacts on the quality and
duration of graft and patient survival, contributing to higher costs as numerous interventions …

The shortage of donor livers considered suitable for transplantation has driven the
development of novel methods for organ preservation and reconditioning. Machine …

A short period (1–2 h) of hypothermic oxygenated machine perfusion (HOPE) after static
cold storage is safe and reduces ischemia‐reperfusion injury‐related complications after …

Conclusions: HMP-O 2 demonstrates safety and noninferior efficacy for liver graft
preservation in comparison to SCS. Early allograft failure by L-GrAFT 7 was lower in HMP-O …

Hepatic ischemia reperfusion injury (HIRI) is a major hurdle in many clinical scenarios,
including liver resection and transplantation. Various studies and countless surgical events …

Background Liver transplantation is traditionally performed around the clock to minimize
organ ischemic time. However, the prospect of prolonging preservation times holds the …

Oxygenated ex situ machine perfusion of donor livers is an alternative for static cold
preservation that can be performed at temperatures from 0° C to 37° C. Organ metabolism …

Mitochondria sense changes resulting from the ischemia and subsequent reperfusion of an
organ and mitochondrial reactive oxygen species (ROS) production initiates a series of …

Liver transplantation is the only recognized effective treatment for end-stage liver disease.
However, organ shortages have become the main challenge for patients and physicians …

Organ transplantation is a multifactorial process in which proper graft preservation is a
mandatory step for the success of the transplantation. Hypothermic preservation of …