Post-transcriptional mechanisms are key determinants in the modulation of the expression of
final gene products. Within this context, fundamental players are RNA-binding proteins …

AU-rich element-binding proteins (AUBPs) represent important post-transcriptional
regulators of gene expression. AUBPs can bind to the AU-rich elements present in the 3' …

Gene expression patterns vary dramatically in a tissue-specific and age-dependent manner.
RNA-binding proteins that regulate mRNA turnover and/or translation (TTR-RBPs) critically …

The Fos oncogene gene family is evolutionarily conserved throughout Eukarya. Fos proteins
characteristically have a leucine zipper and a basic region with a helix-turn-helix motif that …

Human antigen R (HuR) is a member of the embryonic lethal abnormal vision (ELAV) family
which can bind to the A/U rich elements in 3'un-translated region of mRNA and regulate …

Although tumors tend to be associated with immune cells and inflammation, this immune
response often fails to eliminate the cancer and instead promotes cancer progression …

Genito-urinary malignancies (prostate, bladder, renal and testicular cancers) rank high
among human tumors with an incidence that varies with age and organ involvement …

Gene expression patterns vary dramatically in a tissue-specific and age-dependent manner.
RNA-binding proteins that regulate mRNA turnover and/or translation (TTR-RBPs) critically …

Introduction 3. Alternative splicing and alternative polyadenylation, au-rich element function
and disease 3.1. Alternative splicing affecting ARE function 3.1. 1. The ARE-binding protein …

Suberoylanilide hydroxamic acid (SAHA) inhibiting cancer cell growth has been associated
with its downregulation of cyclin D1 protein expression at transcription level or translation …