Background: The long-term risk for major bleeding in patients receiving extended (beyond
the initial 3 to 6 months) anticoagulant therapy for a first unprovoked venous …

Air pollution exerts several deleterious effects on the cardiovascular system, with
cardiovascular disease (CVD) accounting for 80% of all premature deaths caused by air …

We report a genome-wide association study of venous thromboembolism (VTE)
incorporating 81,190 cases and 1,419,671 controls sampled from six cohorts. We identify 93 …

Thrombotic cerebro-cardiovascular diseases are the leading causes of disability and death
worldwide. However, current drug therapeutics are compromised by narrow therapeutic …

Intravascular neutrophils and platelets collaborate in maintaining host integrity, but their
interaction can also trigger thrombotic complications. We report here that cooperation …

Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary
embolism is a major cause of morbidity and mortality. Short-term immobility-related …

Anticoagulants are the cornerstone for prevention and treatment of thrombosis but are not
completely effective, and concerns about the risk of bleeding continue to limit their uptake …

Cardiovascular disease (CVD) and cancer are the leading causes of death worldwide. With
an increasing number of the elderly population, and early cancer screening and treatment …

As the third most common vascular disease, venous thromboembolism is associated with
significant mortality and morbidity. Pathogenesis underlying venous thrombosis is still not …

Due to the high recurrence rate and mortality of venous thrombosis, there is an urgent need
for research on antithrombotic strategies. Because of the short half‐life, poor targeting …