Direct Oral Anticoagulants: Navigating Through Clinical Challenges

M Ioannou, E Leonidou, I Chaziri… - Cardiovascular Drugs and …, 2023 - Springer
Abstract Purpose Direct oral anticoagulants (DOACs) have been approved, for over a
decade, by both European and American medicine agencies, for treatment and prevention …

Direct oral anticoagulants versus warfarin in nonvalvular atrial fibrillation patients with prior gastrointestinal bleeding: a network meta-analysis of real-world data

W Hu, H Cai, J Zhang - European Journal of Clinical Pharmacology, 2022 - Springer
Purpose The objective of present study was to compare the safety and efficacy of resuming
direct-acting oral anticoagulants (DOACs) and vitamin K antagonists (VKAs) in patients with …

Evaluation of Apixaban safety and effectiveness in morbidly obese patients with atrial fibrillation: a retrospective cohort study

K Al Sulaiman, HA Badreldin, GB Korayem… - Thrombosis …, 2022 - Springer
Background The benefit of apixaban to reduce stroke risk in morbidly obese patients with
nonvalvular atrial fibrillation (AF) is still undetermined. The International Society of …

Impact of Obesity on Atrial Fibrillation Pathogenesis and Treatment Options

R Sha, O Baines, A Hayes, K Tompkins… - Journal of the …, 2024 - Am Heart Assoc
Atrial fibrillation (AF) is the most common cardiac arrhythmia. AF increases the risk of stroke,
heart failure, dementia, and hospitalization. Obesity significantly increases AF risk, both …

Single versus dual antiplatelet therapy following left atrial appendage occlusion in patients with high bleeding risk

M Mhanna, A Beran, A Al-Abdouh, A Jabri… - Current Problems in …, 2022 - Elsevier
Our study aims to compare the utility of single antiplatelet therapy (SAPT) with dual
antiplatelet therapy (DAPT) following Left atrial appendage occlusion in patients whose post …

Therapeutic Drug Monitoring of Direct Oral Anticoagulants in Patients with Extremely Low and High Body Weight—Pilot Study

Ł Wołowiec, M Kusiak, J Budzyński… - Journal of Clinical …, 2023 - mdpi.com
Phase III clinical trials for individual direct oral anticoagulants (DOACs) contained a limited
representation of subjects with abnormal body weight, which were mostly limited to a BMI> …

Comparing the clinical outcomes observed with rivaroxaban versus warfarin for the management of obese patients with non-valvular atrial fibrillation: a systematic …

X Zhuo, J Wang, L Shao - Cardiovascular Drugs and Therapy, 2024 - Springer
Background Atrial fibrillation (AF) is an irregular heart rhythm which is becoming more and
more common in this new era. Obesity is a risk factor for cardiovascular events, and obese …

Factor Xa Inhibitors versus warfarin in patients with morbid obesity and atrial fibrillation

P Dobry, K McGrew, I Yun, R Heath, A Shafqat… - European Journal of …, 2024 - Springer
Purpose Factor Xa Inhibitors have emerged as a first-line agent in the management of non-
valvular atrial fibrillation (NVAF), but there is a need for additional data surrounding their use …

Safety and efficacy of direct oral anticoagulants in comparison to warfarin in obese patients with atrial fibrillation: A systematic review and meta‐analysis

A Adelkhanova, PR Oli, DB Shrestha… - Health Science …, 2024 - Wiley Online Library
Abstract Background and Aim Obesity affects nearly 650 million adults worldwide, and the
prevalence is steadily rising. This condition has significant adverse effects on cardiovascular …

[PDF][PDF] The Effectiveness and Safety of Direct Oral Anticoagulants in Obese Patients With Atrial Fibrillation: A Network Meta-Analysis

QM Salah, S Bhandari, A Chand, S Khan, SHA Tirmzi… - Cureus, 2023 - cureus.com
Atrial fibrillation (AF) is a cardiac condition characterized by an irregular heart rhythm, which
is increasingly prevalent in the modern era. All international guidelines strongly advise the …